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JNCI Journal of the National Cancer Institute 2002 94(17):1336; doi:10.1093/jnci/94.17.1336
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 17, 1336, September 4, 2002
© 2002 Oxford University Press

CORRESPONDENCE

Re: The Effects of Tamoxifen and Estrogen on Brain Metabolism in Elderly Women

John R. Benson

Correspondence to: John R. Benson, M.A., D.M., Cambridge Breast Unit, Box 97, Addenbrooke's Hospital, Hills Rd., Cambridge, U.K. CB2 2QQ (e-mail: john.benson@addenbrooke's.nhs.uk).

The first 10% of the full text of this article appears below.

Tamoxifen is a selective estrogen receptor modulator (SERM) with mixed agonist/antagonist properties and variable, though consistent, effects upon target tissues. Although tamoxifen confers beneficial properties of an estrogen agonist on bone and on the cardiovascular system, it remains unclear how tamoxifen might influence the central nervous system or cognitive ability. The occurrence of hot flashes, a common side . . . [Full Text of this Article]


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