© 2002 by Oxford University Press
Journal of the National Cancer Institute, Vol. 94, No. 16, 1194-1195,
August 21, 2002
© 2002 Oxford University Press
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Heat Shock Protein Inhibitor Shows Antitumor Activity
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In an oncologic twist of the classic happenstance discovery of penicillin, fungus-derived antibiotics are moving toward phase II clinical trials for their anti-tumor effects in hard-to-treat leukemia, breast, prostate, lung, and ovarian cancers.
Several rounds of laboratory, animal, and early human studies have produced encouraging results with the drug 17-allylaminogeldanamycin (17AAG), used as a single agent or in combination with conventional chemotherapy. The drug appears to work by interfering with heat shock protein 90 (Hsp90), a stress-induced molecule abundant in tumor cells.
The National Cancer Institute is
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