© 2002 by Oxford University Press
Journal of the National Cancer Institute, Vol. 94, No. 11, 793-795,
June 5, 2002
© 2002 Oxford University Press
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Silence of the Genes: Cancer Epigenetics Arrives
A surging interest in epigenetics—changes in gene expression that occur without changes in DNA sequence—stems from a series of stunning discoveries over the past decade that have elevated the field from backwater status to the forefront of cancer research.
The packed talks at the recent American Association for Cancer Research annual meeting proved that epigenetics has arrived. "It clearly looks like this field has gained acceptance," remarked Rudolph Jaenisch, M.D., of MIT’s Whitehead Institute, surveying hundreds of people jammed into his lecture hall. "About 5, 6 years ago at a similar symposium, I think there were about double as many listeners as speakers."
Epigenetics is now firmly linked to cancer progression. Just in the last 6 months, the two main branches of epigenetic research, DNA methylation
Making the Cancer Connection
Chromatin Takes Center Stage
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