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JNCI Journal of the National Cancer Institute 2002 94(1):1; doi:10.1093/jnci/94.1.1
© 2002 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 94, No. 1, 1, January 2, 2002
© 2002 Oxford University Press

IN THIS ISSUE

Matrix Metalloproteinase, Bone Turnover, and Prostate Cancer

Metastasis of prostate cancer to the bone is associated with increased turnover of the bone matrix. Because matrix metalloproteinases (MMPs) are involved in both the normal remodeling of bone and metastasis of prostate cancer, Nemeth et al. (p. 17) investigated the role of MMP activity in prostate cancer metastasis to the bone. They used a mouse model of prostate cancer metastasis where prostate cancer cells are injected into implanted human bone fragments. They observed that inhibiting MMP activity with batimastat reduced the number of osteoclasts per millimeter of bone, prevented bone degradation, and reduced the . . . [Full Text of this Article]

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