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JNCI Journal of the National Cancer Institute 2001 93(7):554-555; doi:10.1093/jnci/93.7.554
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 7, 554-555, April 4, 2001
© 2001 Oxford University Press

CORRESPONDENCE

Re: CYP17 Promoter Polymorphism and Breast Cancer in Australian Women Under Age Forty Years

Helena Jernström, Danny Vesprini, H. Leon Bradlow, Steven A. Narod

Affiliations of authors: H. Jernström, Centre for Research in Women's Health, Toronto, ON, Canada, and The Jubileum Institute, Department of Oncology, University Hospital, Lund, Sweden; D. Vesprini, S. A. Narod, Centre for Research in Women's Health, Toronto; H. L. Bradlow, Strang Cancer Research Laboratory, New York, NY.

Correspondence to: Steven A. Narod, M.D., FRCPC, Centre for Research in Women's Health, 790 Bay St., 7th floor, Toronto, ON, M5G 1N8 Canada (e-mail: steven.narod@swchsc.on.ca).

Spurdle et al. (1) reported a positive association between the CC genotype of the CYP17 gene and the risk of breast cancer in young Australian women. This polymorphism is the result of a T to C transition in the 5` untranslated region of the gene. Among women with breast cancer and a first- or second-degree relative with breast cancer, 23% had a CC variant compared with 11% in control subjects (two-sided P = . . . [Full Text of this Article]

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