© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 4, 309-314,
February 21, 2001
© 2001 Oxford University Press
REPORT |
Levels of Hypoxia-Inducible Factor-1
During Breast Carcinogenesis
Affiliations of authors: R. Bos, E. C. M. Mommers, P. J. van Diest (Department of Pathology), H. M. Pinedo, E. van der Wall (Department of Medical Oncology), Free University Hospital, Amsterdam, The Netherlands; H. Zhong, J. W. Simons, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA; C. F. Hanrahan (Brady Urological Institute), G. L. Semenza (Departments of Pediatrics and Medicine, Institute of Genetic Medicine), M. D. Abeloff (Oncology Center), The Johns Hopkins University School of Medicine, Baltimore, MD.
Correspondence to: Elsken van der Wall, M.D., Ph.D., Department of Medical Oncology, Free University Hospital, P.O. Box 7057, NL-1007 MB Amsterdam, The Netherlands (e-mail: e.vanderwall{at}azvu.nl).
Background: Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates gene expression in critical pathways involved in tumor growth and metastases. In this report, we investigated whether the level of HIF-1
is increased during carcinogenesis in breast tissue and is associated with other tumor biomarkers. Methods: Paraffin-embedded clinical specimens from five pathologic stages of breast tumorigenesis and from normal breast tissue were used. HIF-1 protein and the biomarkers vascular endothelial growth factor (VEGF), HER-2/neu, p53, Ki-67, and estrogen receptor (ER) were identified immunohistochemically, and microvessel density (a measure of angiogenesis) was determined. Associations among levels of HIF-1 and these biomarkers were tested statistically. All statistical tests are two-sided. Results: The frequency of HIF-1-positive cells in a specimen increased with the specimen's pathologic stage (P<.001, 
2 test for trend) as follows: normal breast tissue (0 specimens with 
1% HIF-1-positive cells in 10 specimens tested), ductal hyperplastic lesions (0 in 10), well-differentiated ductal carcinomas in situ (DCIS) (11 in 20), well-differentiated invasive breast cancers (12 in 20), poorly differentiated DCIS (17 in 20), and poorly differentiated invasive carcinomas (20 in 20). Increased levels of HIF-1 were statistically significantly associated with high proliferation and increased expression of VEGF and ER proteins. In DCIS lesions, increased levels of HIF-1 were statistically significantly associated with increased microvessel density. HIF-1 showed a borderline association with HER-2/neu but no association with p53. Conclusions: The level of HIF-1 increases as the pathologic stage increases and is higher in poorly differentiated lesions than in the corresponding type of well-differentiated lesions. Increased levels of HIF-1 are associated with increased proliferation and increased expression of ER and VEGF. Thus, increased levels of HIF-1 are potentially associated with more aggressive tumors.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Chen, I. Cuevas, P. A. Kenny, H. Miyake, K. Mace, C. Ghajar, A. Boudreau, M. Bissell, and N. Boudreau Endothelial Cell Migration and Vascular Endothelial Growth Factor Expression Are the Result of Loss of Breast Tissue Polarity Cancer Res., August 15, 2009; 69(16): 6721 - 6729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. MOSER, S. A. LANG, and O. STOELTZING Heat-shock Protein 90 (Hsp90) as a Molecular Target for Therapy of Gastrointestinal Cancer Anticancer Res, June 1, 2009; 29(6): 2031 - 2042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Thangasamy, J. Rogge, and S. Ammanamanchi Recepteur d'Origine Nantais Tyrosine Kinase Is a Direct Target of Hypoxia-inducible Factor-1{alpha}-mediated Invasion of Breast Carcinoma Cells J. Biol. Chem., May 22, 2009; 284(21): 14001 - 14010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Burkitt, S. Y. Chun, D. T. Dang, and L. H. Dang Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment Mol. Cancer Ther., May 1, 2009; 8(5): 1148 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Amir, R. Wang, J. W. Simons, and N. J. Mabjeesh SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation J. Biol. Chem., April 24, 2009; 284(17): 11142 - 11151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, C. K. Veena, J. B. Morgan, K. A. Mohammed, M. B. Jekabsons, D. G. Nagle, and Y.-D. Zhou Methylalpinumisoflavone Inhibits Hypoxia-inducible Factor-1 (HIF-1) Activation by Simultaneously Targeting Multiple Pathways J. Biol. Chem., February 27, 2009; 284(9): 5859 - 5868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Pencreach, E. Guerin, C. Nicolet, I. Lelong-Rebel, A.-C. Voegeli, P. Oudet, A. K. Larsen, M.-P. Gaub, and D. Guenot Marked Activity of Irinotecan and Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the Mammalian Target of Rapamycin/Hypoxia-Inducible Factor-1{alpha} Axis Clin. Cancer Res., February 15, 2009; 15(4): 1297 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Berchner-Pfannschmidt, S. Frede, C. Wotzlaw, and J. Fandrey Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing Eur. Respir. J., July 1, 2008; 32(1): 210 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A Kingsley, P. G J Fournier, J. M Chirgwin, and T. A Guise Molecular Biology of Bone Metastasis Am. Assoc. Cancer Res. Educ. Book, April 12, 2008; 2008(1): 443 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kubo, T. Sugita, S. Shimose, T. Matsuo, K. Arihiro, and M. Ochi Expression of hypoxia-inducible factor-1{alpha} and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours J Bone Joint Surg Br, March 1, 2008; 90-B(3): 364 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Horree, P J van Diest, P van der Groep, D M D S Sie-Go, and A P M Heintz Progressive derailment of cell cycle regulators in endometrial carcinogenesis J. Clin. Pathol., January 1, 2008; 61(1): 36 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rapisarda and G. Melillo HIF-1 Inhibitors: Novel Opportunities for Cancer Therapy ASCO Educational Book, January 1, 2008; 2008(1): 543 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Kingsley, P. G.J. Fournier, J. M. Chirgwin, and T. A. Guise Molecular Biology of Bone Metastasis Mol. Cancer Ther., October 1, 2007; 6(10): 2609 - 2617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J Grimshaw Endothelins and hypoxia-inducible factor in cancer Endocr. Relat. Cancer, June 1, 2007; 14(2): 233 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hiraga, S. Kizaka-Kondoh, K. Hirota, M. Hiraoka, and T. Yoneda Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer Cancer Res., May 1, 2007; 67(9): 4157 - 4163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Langley and I. J. Fidler Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis Endocr. Rev., May 1, 2007; 28(3): 297 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D.W. van der Bilt, M. E. Soeters, A. M.M.J. Duyverman, M. W. Nijkamp, P. O. Witteveen, P. J. van Diest, O. Kranenburg, and I. H.M. Borel Rinkes Perinecrotic Hypoxia Contributes to Ischemia/Reperfusion-Accelerated Outgrowth of Colorectal Micrometastases Am. J. Pathol., April 1, 2007; 170(4): 1379 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Lang, D. Klein, C. Moser, A. Gaumann, G. Glockzin, M. H. Dahlke, W. Dietmaier, U. Bolder, H. J. Schlitt, E. K. Geissler, et al. Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo Mol. Cancer Ther., March 1, 2007; 6(3): 1123 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Liao, C. Corle, T. N. Seagroves, and R. S. Johnson Hypoxia-Inducible Factor-1{alpha} Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression Cancer Res., January 15, 2007; 67(2): 563 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Generali, S. B. Fox, A. Berruti, J. W. Moore, M. P. Brizzi, N. Patel, G. Allevi, S. Bonardi, S. Aguggini, A. Bersiga, et al. Regulation of Hepatocyte Growth Factor Activator Inhibitor 2 by Hypoxia in Breast Cancer Clin. Cancer Res., January 15, 2007; 13(2): 550 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Wilson, J. Burchell, and M. J. Grimshaw Endothelins Induce CCR7 Expression by Breast Tumor Cells via Endothelin Receptor A and Hypoxia-Inducible Factor-1 Cancer Res., December 15, 2006; 66(24): 11802 - 11807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kang, H. T. Cho, S. Devi, Z. Zhang, D. Escuin, Z. Liang, H. Mao, D. J. Brat, J. J. Olson, J. W. Simons, et al. Antitumor Effect of 2-Methoxyestradiol in a Rat Orthotopic Brain Tumor Model Cancer Res., December 15, 2006; 66(24): 11991 - 11997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tanaka, M. Yamamoto, N. Hashimoto, M. Miyakoshi, S. Tamakawa, M. Yoshie, Y. Tokusashi, K. Yokoyama, Y. Yaginuma, and K. Ogawa Hypoxia-Independent Overexpression of Hypoxia-Inducible Factor 1{alpha} as an Early Change in Mouse Hepatocarcinogenesis Cancer Res., December 1, 2006; 66(23): 11263 - 11270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Jones, C. W. Pugh, S. Wigfield, M. F.G. Stevens, and A. L. Harris Novel Thioredoxin Inhibitors Paradoxically Increase Hypoxia-Inducible Factor-{alpha} Expression but Decrease Functional Transcriptional Activity, DNA Binding, and Degradation. Clin. Cancer Res., September 15, 2006; 12(18): 5384 - 5394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S M Hyder Sex-steroid regulation of vascular endothelial growth factor in breast cancer. Endocr. Relat. Cancer, September 1, 2006; 13(3): 667 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Jones and A. L. Harris Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding. Mol. Cancer Ther., September 1, 2006; 5(9): 2193 - 2202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Melillo Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy Mol. Cancer Res., September 1, 2006; 4(9): 601 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sumiyoshi, Y. Kakeji, A. Egashira, K. Mizokami, H. Orita, and Y. Maehara Overexpression of Hypoxia-Inducible Factor 1{alpha} and p53 Is a Marker for an Unfavorable Prognosis in Gastric Cancer Clin. Cancer Res., September 1, 2006; 12(17): 5112 - 5117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Generali, A. Berruti, M. P. Brizzi, L. Campo, S. Bonardi, S. Wigfield, A. Bersiga, G. Allevi, M. Milani, S. Aguggini, et al. Hypoxia-Inducible Factor-1{alpha} Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer Clin. Cancer Res., August 1, 2006; 12(15): 4562 - 4568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Brown, R. L. Cowen, C. Debray, A. Eustace, J. T. Erler, F. C. D. Sheppard, C. A. Parker, I. J. Stratford, and K. J. Williams Reversing Hypoxic Cell Chemoresistance in Vitro Using Genetic and Small Molecule Approaches Targeting Hypoxia Inducible Factor-1 Mol. Pharmacol., February 1, 2006; 69(2): 411 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Isidoro, E. Casado, A. Redondo, P. Acebo, E. Espinosa, A. M. Alonso, P. Cejas, D. Hardisson, J. A. Fresno Vara, C. Belda-Iniesta, et al. Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis Carcinogenesis, December 1, 2005; 26(12): 2095 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Boddy, S. B. Fox, C. Han, L. Campo, H. Turley, S. Kanga, P. R. Malone, and A. L. Harris The Androgen Receptor Is Significantly Associated with Vascular Endothelial Growth Factor and Hypoxia Sensing via Hypoxia-Inducible Factors HIF-1a, HIF-2a, and the Prolyl Hydroxylases in Human Prostate Cancer Clin. Cancer Res., November 1, 2005; 11(21): 7658 - 7663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhang, X. Tang, Q. Y. Lu, Z. F. Zhang, J. Brown, and A. D. Le Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1{alpha} and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells Mol. Cancer Ther., October 1, 2005; 4(10): 1465 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Funasaka, T. Yanagawa, V. Hogan, and A. Raz Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia FASEB J, September 1, 2005; 19(11): 1422 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Liu, A. Howes, J. Lesperance, W. B. Stallcup, C. A. Hauser, K. Kadoya, R. G. Oshima, and R. T. Abraham Antitumor Activity of Rapamycin in a Transgenic Mouse Model of ErbB2-Dependent Human Breast Cancer Cancer Res., June 15, 2005; 65(12): 5325 - 5336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zhao, Y. Kuge, T. Mochizuki, T. Takahashi, K. Nakada, M. Sato, T. Takei, and N. Tamaki Biologic Correlates of Intratumoral Heterogeneity in 18F-FDG Distribution with Regional Expression of Glucose Transporters and Hexokinase-II in Experimental Tumor J. Nucl. Med., April 1, 2005; 46(4): 675 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Schneider and K. D. Miller Angiogenesis of Breast Cancer J. Clin. Oncol., March 10, 2005; 23(8): 1782 - 1790. [Full Text] [PDF]
|
|
|
|
|
|
P J van Diest, M M Vleugel, E van der Wall, M J Currie, V Hanrahan, S P Gunningham, H R Morrin, C Frampton, C Han, B A Robinson, et al. Expression of HIF-1{alpha} in human tumours J. Clin. Pathol., March 1, 2005; 58(3): 335 - 336. [Full Text] [PDF]
|
|
|
|
|
|
M M Vleugel, A E Greijer, A Shvarts, P van der Groep, M van Berkel, Y Aarbodem, H van Tinteren, A L Harris, P J van Diest, and E van der Wall Differential prognostic impact of hypoxia induced and diffuse HIF-1{alpha} expression in invasive breast cancer J. Clin. Pathol., February 1, 2005; 58(2): 172 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Li, Z.-H. Miao, W.-F. Tan, J.-M. Yue, C. Zhang, L.-P. Lin, X.-W. Zhang, and J. Ding Pseudolaric Acid B Inhibits Angiogenesis and Reduces Hypoxia-Inducible Factor 1{alpha} by Promoting Proteasome-Mediated Degradation Clin. Cancer Res., December 15, 2004; 10(24): 8266 - 8274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cooper, G.-Y. Liu, Y.-L. Niu, S. Santos, L. C. Murphy, and P. H. Watson Intermittent Hypoxia Induces Proteasome-Dependent Down-Regulation of Estrogen Receptor {alpha} in Human Breast Carcinoma Clin. Cancer Res., December 15, 2004; 10(24): 8720 - 8727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Giatromanolaki, M. I. Koukourakis, C. Simopoulos, A. Polychronidis, K. C. Gatter, A. L. Harris, and E. Sivridis c-erbB-2 Related Aggressiveness in Breast Cancer Is Hypoxia Inducible Factor-1{alpha} Dependent Clin. Cancer Res., December 1, 2004; 10(23): 7972 - 7977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Skinner, J. Z. Zheng, J. Fang, F. Agani, and B.-H. Jiang Vascular Endothelial Growth Factor Transcriptional Activation Is Mediated by Hypoxia-inducible Factor 1{alpha}, HDM2, and p70S6K1 in Response to Phosphatidylinositol 3-Kinase/AKT Signaling J. Biol. Chem., October 29, 2004; 279(44): 45643 - 45651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rapisarda, J. Zalek, M. Hollingshead, T. Braunschweig, B. Uranchimeg, C. A. Bonomi, S. D. Borgel, J. P. Carter, S. M. Hewitt, R. H. Shoemaker, et al. Schedule-dependent Inhibition of Hypoxia-inducible Factor-1{alpha} Protein Accumulation, Angiogenesis, and Tumor Growth by Topotecan in U251-HRE Glioblastoma Xenografts Cancer Res., October 1, 2004; 64(19): 6845 - 6848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A E Greijer and E van der Wall The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis J. Clin. Pathol., October 1, 2004; 57(10): 1009 - 1014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Stoeltzing, M. F. McCarty, J. S. Wey, F. Fan, W. Liu, A. Belcheva, C. D. Bucana, G. L. Semenza, and L. M. Ellis Role of Hypoxia-Inducible Factor 1{alpha} in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation J Natl Cancer Inst, June 16, 2004; 96(12): 946 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Koike, N. Kimura, K. Miyazaki, T. Yabuta, K. Kumamoto, S. Takenoshita, J. Chen, M. Kobayashi, M. Hosokawa, A. Taniguchi, et al. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates PNAS, May 25, 2004; 101(21): 8132 - 8137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Erler, C. J. Cawthorne, K. J. Williams, M. Koritzinsky, B. G. Wouters, C. Wilson, C. Miller, C. Demonacos, I. J. Stratford, and C. Dive Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance Mol. Cell. Biol., April 1, 2004; 24(7): 2875 - 2889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hopfl, O. Ogunshola, and M. Gassmann HIFs and tumors--causes and consequences Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R608 - R623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zimmer, D. Doucette, N. Siddiqui, and O. Iliopoulos Inhibition of Hypoxia-Inducible Factor Is Sufficient for Growth Suppression of VHL-/- Tumors Mol. Cancer Res., February 1, 2004; 2(2): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S Cherniack Oxygen sensing: applications in humans J Appl Physiol, January 1, 2004; 96(1): 352 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, G. Davidson, Y. Huang, B.-H. Jiang, X. Shi, M. Costa, and C. Huang Nickel Compounds Act through Phosphatidylinositol-3-kinase/Akt-Dependent, p70S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and Cap43 Expression in Mouse Epidermal Cl41 Cells Cancer Res., January 1, 2004; 64(1): 94 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tanimoto, K. Yoshiga, H. Eguchi, M. Kaneyasu, K. Ukon, T. Kumazaki, N. Oue, W. Yasui, K. Imai, K. Nakachi, et al. Hypoxia-inducible factor-1{alpha} polymorphisms associated with enhanced transactivation capacity, implying clinical significance Carcinogenesis, November 1, 2003; 24(11): 1779 - 1783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Woelfle, J. Cloos, G. Sauter, L. Riethdorf, F. Janicke, P. van Diest, R. Brakenhoff, and K. Pantel Molecular Signature Associated with Bone Marrow Micrometastasis in Human Breast Cancer Cancer Res., September 15, 2003; 63(18): 5679 - 5684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Mabjeesh, M. T. Willard, C. E. Frederickson, H. Zhong, and J. W. Simons Androgens Stimulate Hypoxia-inducible Factor 1 Activation via Autocrine Loop of Tyrosine Kinase Receptor/Phosphatidylinositol 3'-Kinase/Protein Kinase B in Prostate Cancer Cells Clin. Cancer Res., July 1, 2003; 9(7): 2416 - 2425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. N. Seagroves, D. Hadsell, J. McManaman, C. Palmer, D. Liao, W. McNulty, B. Welm, K.-U. Wagner, M. Neville, and R. S. Johnson HIF1{alpha} is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland Development, April 15, 2003; 130(8): 1713 - 1724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Helczynska, A. Kronblad, A. Jogi, E. Nilsson, S. Beckman, G. Landberg, and S. Pahlman Hypoxia Promotes a Dedifferentiated Phenotype in Ductal Breast Carcinoma in Situ Cancer Res., April 1, 2003; 63(7): 1441 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Krishnamachary, S. Berg-Dixon, B. Kelly, F. Agani, D. Feldser, G. Ferreira, N. Iyer, J. LaRusch, B. Pak, P. Taghavi, et al. Regulation of Colon Carcinoma Cell Invasion by Hypoxia-Inducible Factor 1 Cancer Res., March 1, 2003; 63(5): 1138 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V.-M. Wasenius, S. Hemmer, E. Kettunen, S. Knuutila, K. Franssila, and H. Joensuu Hepatocyte Growth Factor Receptor, Matrix Metalloproteinase-11, Tissue Inhibitor of Metalloproteinase-1, and Fibronectin Are Up-Regulated in Papillary Thyroid Carcinoma: A cDNA and Tissue Microarray Study Clin. Cancer Res., January 1, 2003; 9(1): 68 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A J Rice, M A Steward, and C M Quinn Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast J. Clin. Pathol., December 1, 2002; 55(12): 921 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Adeyinka, E. Emberley, Y. Niu, L. Snell, L. C. Murphy, H. Sowter, C. C. Wykoff, A. L. Harris, and P. H. Watson Analysis of Gene Expression in Ductal Carcinoma in Situ of the Breast Clin. Cancer Res., December 1, 2002; 8(12): 3788 - 3795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cuezva, M. Krajewska, M. L. de Heredia, S. Krajewski, G. Santamaria, H. Kim, J. M. Zapata, H. Marusawa, M. Chamorro, and J. C. Reed The Bioenergetic Signature of Cancer: A Marker of Tumor Progression Cancer Res., November 15, 2002; 62(22): 6674 - 6681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stoner, B. Saville, M. Wormke, D. Dean, R. Burghardt, and S. Safe Hypoxia Induces Proteasome-Dependent Degradation of Estrogen Receptor {alpha} in ZR-75 Breast Cancer Cells Mol. Endocrinol., October 1, 2002; 16(10): 2231 - 2242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Welsh, W. T. Bellamy, M. M. Briehl, and G. Powis The Redox Protein Thioredoxin-1 (Trx-1) Increases Hypoxia-inducible Factor 1{alpha} Protein Expression: Trx-1 Overexpression Results in Increased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis Cancer Res., September 1, 2002; 62(17): 5089 - 5095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rapisarda, B. Uranchimeg, D. A. Scudiero, M. Selby, E. A. Sausville, R. H. Shoemaker, and G. Melillo Identification of Small Molecule Inhibitors of Hypoxia-inducible Factor 1 Transcriptional Activation Pathway Cancer Res., August 1, 2002; 62(15): 4316 - 4324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Rice and C M Quinn Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast J. Clin. Pathol., August 1, 2002; 55(8): 569 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schindl, S. F. Schoppmann, H. Samonigg, H. Hausmaninger, W. Kwasny, M. Gnant, R. Jakesz, E. Kubista, P. Birner, and G. Oberhuber Overexpression of Hypoxia-inducible Factor 1{alpha} Is Associated with an Unfavorable Prognosis in Lymph Node-positive Breast Cancer Clin. Cancer Res., June 1, 2002; 8(6): 1831 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jogi, I. Ora, H. Nilsson, A. Lindeheim, Y. Makino, L. Poellinger, H. Axelson, and S. Pahlman Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype PNAS, May 14, 2002; 99(10): 7021 - 7026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pellizzaro, D. Coradini, and M. G. Daidone Modulation of angiogenesis-related proteins synthesis by sodium butyrate in colon cancer cell line HT29 Carcinogenesis, May 1, 2002; 23(5): 735 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hopfl, R. H. Wenger, U. Ziegler, T. Stallmach, O. Gardelle, R. Achermann, M. Wergin, B. Kaser-Hotz, H. M. Saunders, K. J. Williams, et al. Rescue of Hypoxia-inducible Factor-1{alpha}-deficient Tumor Growth by Wild-Type Cells Is Independent of Vascular Endothelial Growth Factor Cancer Res., May 1, 2002; 62(10): 2962 - 2970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ozaki, J. K. Haseman, J. R. Hailey, R. R. Maronpot, and A. Nyska Association of Adrenal Pheochromocytoma and Lung Pathology in Inhalation Studies with Particulate Compounds in the Male F344 Rat--The National Toxicology Program Experience Toxicol Pathol, February 1, 2002; 30(2): 263 - 270. [Abstract] [PDF]
|
|
|
|
|
|
R. Bos, J. J.M. van der Hoeven, E. van der Wall, P. van der Groep, P. J. van Diest, E. F.I. Comans, U. Joshi, G. L. Semenza, O. S. Hoekstra, A. A. Lammertsma, et al. Biologic Correlates of 18Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography J. Clin. Oncol., January 15, 2002; 20(2): 379 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bos, P. J. van Diest, and E. van der Wall RESPONSE: Re: Levels of Hypoxia-Inducible Factor-1{alpha} During Breast Carcinogenesis J Natl Cancer Inst, August 1, 2001; 93(15): 1177 - 1177. [Full Text] [PDF]
|
|