© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 3, 234-237,
February 7, 2001
© 2001 Oxford University Press
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Parathyroid Hormone-Related Protein Production by Breast Cancers, Improved Survival, and Reduced Bone Metastases
Affiliations of authors: M. A. Henderson, T. L. Harris, M. R. McKinlay, University of Melbourne, Department of Surgery, St. Vincent's Hospital, Fitzroy, Australia; J. A. Danks, J. M. Moseley, T. J. Martin (St. Vincent's Institute of Medical Research), J. L. Slavin (Department of Pathology), St. Vincent's Hospital; J. L. Hopper, Department of General Practice and Public Health, University of Melbourne.
Correspondence to: Michael A. Henderson, M.D., FRACS, Department of Surgery, St. Vincent's Hospital, 41 Victoria Parade, Fitzroy 3065, Victoria, Australia (e-mail: henderson@surgerysvh.unimelb.edu.au).
Metastasis of breast cancers is a common and serious clinical problem, with up to one third of women with early-stage breast cancer eventually dying of the disease. Of all patients with distant spread of the cancer, 70% have bone metastases (1,2), reflective of the observations of Paget (3) that breast cancers had a particular predilection to grow in bone. A special property required of cancer cells for growth as metastases in bone is the ability to promote bone resorption by inducing the formation and activity of osteoclasts (4). Parathyroid hormone-related protein (PTHrP) is produced by two thirds of primary breast cancers (5), promotes osteoclast formation and bone resorption, and has been implicated in site-specific metastasis of breast cancer to bone (6). The current study investigated the relationship among detection of PTHrP in primary breast cancers, development of skeletal
NOTES
Presented in part at the 21st Annual Meeting of the American Society for Bone and Mineral Research, St. Louis (MO), in September 1999 and at the 90th Annual Meeting of the American Association for Cancer Research, Philadelphia (PA), in March 1999.
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