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JNCI Journal of the National Cancer Institute 2001 93(23):1762-1763; doi:10.1093/jnci/93.23.1762
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 23, 1762-1763, December 5, 2001
© 2001 Oxford University Press

EDITORIAL

Breast Cancer Risk Prediction: Should Nipple Aspiration Fluid Cytology Be Incorporated Into Clinical Practice?

Carol J. Fabian, Bruce F. Kimler

Affiliations of authors: C. J. Fabian (Department of Internal Medicine), B. F. Kimler (Department of Radiation Oncology), University of Kansas Medical Center, Kansas City, KS.

Correspondence to: Carol J. Fabian, M.D., University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160–7320 (e-mail: cfabian@kumc.edu).

The burgeoning interest in biomarkers of short-term risk for breast cancer stems from their potential to supplement epidemiologic models in selection of individuals for risk-reduction therapy and to serve as response indicators in chemoprevention trials (1,2). The modified Gail model, which predicts short- and longer-term risk on the basis of a number of personal and family history variables, is validated, easy to use, and widely available (3,4) but has modest discriminatory value at an individual level (5). Using data from the Nurses' Health Study, Rockhill et al. (5) observed that only a small minority of women developing breast cancer within a 5-year period . . . [Full Text of this Article]

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