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JNCI Journal of the National Cancer Institute 2001 93(21):1588-1589; doi:10.1093/jnci/93.21.1588
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 21, 1588-1589, November 7, 2001
© 2001 Oxford University Press

EDITORIAL

Lessons Learned From Lymphocytes: CC Chemokine Receptor-7 Involved in Lymphogenic Metastasis of Melanoma

Reinhold Förster, Lars Ohl, Golo Henning

Affiliation of authors: Section of Experimental Surgery and Immunology, University Clinic for Surgery and Nikolaus-Fiebiger-Center, Erlangen, Germany.

Correspondence to: Professor Dr. Reinhold Förster, Section of Experimental Surgery and Immunology, University of Erlangen, Glückstr. 6, D-91054 Erlangen, Germany (e-mail: rfoerste@molmed.uni-erlangen.de).

The metastatic potential of primary tumors is the chief prognostic determinant of malignant disease (1). Although distinct patterns of metastasis have long been recognized by clinicians, the underlying molecular mechanisms along with the alterations in gene expression of tumor cells required for these processes have begun to emerge only recently. Metastasis and invasion are regulated by extensive interactions and signaling events between the tumor and the local host tissue [reviewed in (2)]. Two principal pathways of metastasis can be distinguished: lymphogenic metastasis to regional lymph nodes and hematogenic metastasis to distant organs. Lately, it has become clear that the two major routes of metastasis, through the lymphatic system and the . . . [Full Text of this Article]

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