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JNCI Journal of the National Cancer Institute 2001 93(20):1512-1513; doi:10.1093/jnci/93.20.1512
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 20, 1512-1513, October 17, 2001
© 2001 Oxford University Press

EDITORIAL

A Predisposition Supposition for Glioma

Kenneth J. Dornfeld, Theodore S. Lawrence

Affiliation of authors: Department of Radiation Oncology, University of Michigan, Ann Arbor.

Correspondence to: Theodore S. Lawrence, M.D., Ph.D., Department of Radiation Oncology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI 48109 (e-mail: tsl@umich.edu).

Who is at risk for developing a brain tumor? Exposure to some agents, such as vinyl chloride or radiation, may increase the risk. A family history of glioma can also be a risk factor, accounting for approximately 2% of glioma patients (1). However, the known causes of glioma represent only a small percentage of patients, with most cases arising "spontaneously." Could a more subtle genetic predisposition underlie the etiology of gliomas?

In this issue of the Journal, Bondy et al. (2) have attempted to uncover differences between glioma patients and normal control subjects that may explain why some people develop gliomas. Using an agent known to induce gliomas in a small number of patients, namely {gamma}-radiation, Bondy et al. measured the frequency . . . [Full Text of this Article]

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