© 2001 by Oxford University Press
Journal of the National Cancer Institute, Vol. 93, No. 2, 148-150,
January 17, 2001
© 2001 Oxford University Press
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Epstein-Barr Virus Detection in Ductal Carcinoma of the Breast
Affiliations of authors: S. A. McCall, J. H. Lichy, K. E. Bijwaard, J. K. Taubenberger (Division of Molecular Pathology, Department of Cellular Pathology), N. S. Aguilera, W.-S. Chu (Department of Lymphatic and Hematologic Pathology), Armed Forces Institute of Pathology, Washington, DC.
Correspondence to: LTC Sherman A. McCall, M.D., Department of Cellular Pathology, Armed Forces Institute of Pathology, 14th St. and Alaska Ave., N.W., Washington, DC 20306-6000 (e-mail: McCall@afip.osd.mil).
Epstein-Barr virus (EBV) has been strongly linked with African Burkitt's lymphoma and nasopharyngeal carcinoma (NPC) and has recently been associated with breast cancer (1). Nine studies of EBV in breast cancer with the use of different methods (1–9) present conflicting results.
In the current study, microdissected ductal breast carcinomas were tested for EBV. Only one of 115 cases was positive. This finding stands in contrast to results of studies of ductal carcinoma showing up to 48% EBV positivity by polymerase chain reaction (PCR).
Bonnet et al. (1) found 51 of 100 breast cancers of all types to be PCR positive for EBV. EBV positivity was also shown by Southern blot analysis and immunostain in a subset of cases, but in situ hybridization (ISH) for EBER was negative. A similar
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