Skip Navigation

JNCI Journal of the National Cancer Institute 2001 93(15):1171-1173; doi:10.1093/jnci/93.15.1171
© 2001 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Horikawa, I.
Right arrow Articles by Barrett, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horikawa, I.
Right arrow Articles by Barrett, J. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 93, No. 15, 1171-1173, August 1, 2001
© 2001 Oxford University Press

BRIEF COMMUNICATION

cis-Activation of the Human Telomerase Gene (hTERT) by the Hepatitis B Virus Genome

Izumi Horikawa, J. Carl Barrett

Affiliation of authors: Laboratory of Biosystems and Cancer, Cancer and Aging Section, Division of Basic Sciences, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

Correspondence to: Izumi Horikawa, Ph.D., National Institutes of Health, Bldg. 40, Rm. 2609, MSC-3020, Bethesda, MD 20892–3020 (e-mail: horikawi@mail.nih.gov).

Telomerase catalyzes the elongation of telomeric repeat DNA to maintain telomere length and structure (1). Although telomerase is a complex composed of a catalytic subunit (hTERT) and an RNA component (hTER), it is the expression of hTERT (2,3) that is the major determinant of telomerase activity in human cells (1,4). Maintaining telomere length by telomerase is associated with human cell immortalization and oncogenesis (1); however, no mutations in the hTERT or hTER telomerase genes have been found in human cancers. Hepatocellular carcinoma is often associated with both telomerase activation and viral infection. Here, we show the cis-activation of the hTERT gene by an insertion of viral DNA into the hTERT promoter region.

A 66-base-pair (bp) sequence within the promoter region of hTERT gene (positions -372 to -307) (Fig. 1Go, . . . [Full Text of this Article]

REFERENCES


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GutHome page
F Luan, H Liu, L Gao, J Liu, Z Sun, Y Ju, N Hou, C Guo, X Liang, L Zhang, et al.
Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT
Gut, November 1, 2009; 58(11): 1528 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. Bellon and C. Nicot
Regulation of Telomerase and Telomeres: Human Tumor Viruses Take Control
J Natl Cancer Inst, January 16, 2008; 100(2): 98 - 108.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. A. Katzenellenbogen, E. M. Egelkrout, P. Vliet-Gregg, L. C. Gewin, P. R. Gafken, and D. A. Galloway
NFX1-123 and Poly(A) Binding Proteins Synergistically Augment Activation of Telomerase in Human Papillomavirus Type 16 E6-Expressing Cells
J. Virol., April 15, 2007; 81(8): 3786 - 3796.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
Y Murakami, K Saigo, H Takashima, M Minami, T Okanoue, C Brechot, and P Paterlini-Brechot
Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas
Gut, August 1, 2005; 54(8): 1162 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. A. Lanson Jr., P. L. Friedlander, P. Schwarzenberger, J. K. Kolls, and G. Wang
Replication of an Adenoviral Vector Controlled by the Human Telomerase Reverse Transcriptase Promoter Causes Tumor-Selective Tumor Lysis
Cancer Res., November 15, 2003; 63(22): 7936 - 7941.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
I. Horikawa and J. C. Barrett
Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms
Carcinogenesis, July 1, 2003; 24(7): 1167 - 1176.
[Abstract] [Full Text] [PDF]