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JNCI Journal of the National Cancer Institute 2001 93(14):1103-1106;
© 2001 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 93, No. 14, 1103-1106, July 18, 2001
© 2001 Oxford University Press

BRIEF COMMUNICATION

Induction of Atypical Ductal Hyperplasia in Mouse Mammary Gland Organ Culture

Rajendra G. Mehta, Krishna P. L. Bhat, Michael E. Hawthorne, Levy Kopelovich, Rajeshwari R. Mehta, Konstantin Christov, Gary J. Kelloff, Vernon E. Steele, John M. Pezzuto

Affiliations of authors: R. G. Mehta, M. E. Hawthorne, R. R. Mehta, K. Christov (Department of Surgical Oncology, College of Medicine), K. P. L. Bhat, J. M. Pezzuto (Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy), University of Illinois at Chicago; L. Kopelovich, G. J. Kelloff, V. E. Steele, Chemopreventive Agent Development Group, Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD.

Correspondence to: John M. Pezzuto, Ph.D., Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy (M/C 877), University of Illinois at Chicago, 833 South Wood St., Chicago, IL 60612 (e-mail: jpezzuto@uic.edu).

Mammary glands undergo morphologic and biochemical changes during various physiologic stages of life, specifically during the transition from virgin to pregnancy, lactation, and involution (1–3). The complete cycle of structural and functional differentiation depends on the coordinated action of prolactin, insulin, adrenal corticoids, and ovarian hormones (4,5). Atypical ductal hyperplasia is an abnormal ductal epithelial cell proliferative condition that does not invade the periductal stroma (6). In women, atypical ductal hyperplasia, which may become more aggressive and ultimately fill the lumen of the duct, is considered to be a physiologic precursor to the development of ductal carcinoma in situ (DCIS).

Although the histopathology of DCIS subtypes is well defined, there are few experimental models to evaluate the molecular mechanisms underlying DCIS formation or to evaluate cancer chemopreventive agents. One model is the mouse mammary gland organ culture (MMOC) (7. . . [Full Text of this Article]

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