Skip Navigation

JNCI Journal of the National Cancer Institute 2001 93(1):45-50; doi:10.1093/jnci/93.1.45
© 2001 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Zhang, J.
Right arrow Articles by Cheng, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, J.
Right arrow Articles by Cheng, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 93, No. 1, 45-50, January 3, 2001
© 2001 Oxford University Press

REPORT

Detecting Bladder Cancer in the Chinese by Microsatellite Analysis: Ethnic and Etiologic Considerations

Jianjun Zhang, Zhenbin Fan, Yanning Gao, Zejun Xiao, Changling Li, Qian An, Shujun Cheng

Affiliations of authors: J. Zhang, Z. Fan, Y. Gao, Q. An, S. Cheng (Department of Chemical Etiology and Carcinogenesis), Z. Xiao, C. Li (Department of Urology), Cancer Institute (Hospital), Chinese Academy of Medical Science and Peking Union Medical College, Beijing.

Correspondence to: Shujun Cheng, M.D., Department of Chemical Etiology and Carcinogenesis, Cancer Institute (Hospital), CAMS and PUMC, P.O. Box 2258, Beijing 100021, People's Republic of China (e-mail: chengsj{at}pubem.cicams.ac.cn

Background: Microsatellite analysis of urine sediments has shown promise as a highly sensitive and specific technique for the detection of bladder cancer. However, most studies have been conducted in Western countries with Caucasian subjects. We explored the potential of microsatellite analysis for detecting bladder cancer in Chinese people. Methods: We performed microsatellite analysis of surgical specimens and urine sediment cells collected from Chinese patients with bladder tumors. Those microsatellite markers giving clearly readable patterns and showing susceptibility to alterations were used as a panel to detect primary tumors. A blinded study of additional patients with bladder cancer was performed to investigate the practical value of this panel for detecting bladder cancer. All statistical tests were two-sided. Results: Thirty-eight bladder tumors and corresponding urine sediment specimens were initially screened for 60 microsatellite markers from 18 chromosomes. Nine markers, most of which were different from those that had been used for Western patients, with frequent alterations in the initial patients were selected for further analysis. In the subsequent blinded experiment, microsatellite alterations were observed in urine sediments from 22 (96%) of 23 patients with bladder cancer and from all three patients with inverted papilloma. None of the urine sediments from the one patient with bladder lipoma, from the one patient with neurofibroma, or from the 12 individuals without evidence of bladder tumor showed any microsatellite alterations. Conclusions: Microsatellite analysis of urine sediments could be a practical method for detecting bladder cancer in the Chinese. Our identification of different microsatellite markers highlights possible ethnic and etiologic disparities between the Chinese and Western bladder cancer patients.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
J. Zhang, S. Zheng, Y. Gao, J. A. Rotolo, Z. Xiao, C. Li, and S. Cheng
A partial allelotyping of urothelial carcinoma of bladder in the Chinese
Carcinogenesis, March 1, 2004; 25(3): 343 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. W. G. van Rhijn, I. Lurkin, D. K. Chopin, W. J. Kirkels, J.-P. Thiery, T. H. van der Kwast, F. Radvanyi, and E. C. Zwarthoff
Combined Microsatellite and FGFR3 Mutation Analysis Enables a Highly Sensitive Detection of Urothelial Cell Carcinoma in Voided Urine
Clin. Cancer Res., January 1, 2003; 9(1): 257 - 263.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.