© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 3, 266-269,
February 2, 2000
© 2000 Oxford University Press
BRIEF COMMUNICATIONS |
Dietary Folate Consumption and Breast Cancer Risk
Affiliations of authors:T. E. Rohan, M. G. Jain, A. B. Miller, Department of Public Health Sciences, University of Toronto, ON, Canada; G. R. Howe, Division of Epidemiology, School of Public Health, Columbia University, New York, NY.
Correspondence to: Thomas E. Rohan, M.B., B.S., Ph.D., Department of Public Health Sciences, University of Toronto, McMurrich Building, 3rd Floor, 12 Queen's Park Crescent West, Toronto M5S 1A8, ON, Canada (e-mail: tom.rohan@utoronto.ca).
Deficient dietary folate intake may predispose individuals to
cancer as a consequence of disruption of DNA synthesis, repair, and
methylation (1,2); diets deficient in methyl groups may result
in the activation of oncogenes and inactivation of tumor suppressor
genes (3). Relatively low intake of methionine and relatively
high intake of alcohol may increase folate requirements, the former by
reducing the availability of methyl groups (4) and the latter
by interfering with folate metabolism (5). Epidemiologic
evidence linking dietary folate, methionine, and alcohol intake with
cancer risk is limited. Two prospective studies (6,7) showed
that diets low in folate and methionine and high in alcohol were
associated with increased risk of colorectal adenomas and of colon
cancer, respectively. Another prospective study (8) showed an
increased risk of recurrence of colorectal adenoma in
NOTES
REFERENCES
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Chanson, L. D Parnell, E. D Ciappio, Z. Liu, J. W Crott, K. L Tucker, and J. B Mason Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1927 - 1936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Genkinger, D. Spiegelman, K. E. Anderson, L. Bergkvist, L. Bernstein, P. A. van den Brandt, D. R. English, J. L. Freudenheim, C. S. Fuchs, G. G. Giles, et al. Alcohol Intake and Pancreatic Cancer Risk: A Pooled Analysis of Fourteen Cohort Studies Cancer Epidemiol. Biomarkers Prev., March 1, 2009; 18(3): 765 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S Maruti, C. M Ulrich, and E. White Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk Am. J. Clinical Nutrition, February 1, 2009; 89(2): 624 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Larsson, L. Bergkvist, and A. Wolk Folate Intake and Risk of Breast Cancer by Estrogen and Progesterone Receptor Status in a Swedish Cohort Cancer Epidemiol. Biomarkers Prev., December 1, 2008; 17(12): 3444 - 3449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B Michels The promise and challenges of population strategies of prevention Int. J. Epidemiol., October 1, 2008; 37(5): 914 - 916. [Full Text] [PDF]
|
|
|
|
|
|
J. Lin, I-M. Lee, N. R Cook, J. Selhub, J. E Manson, J. E Buring, and S. M Zhang Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in women Am. J. Clinical Nutrition, March 1, 2008; 87(3): 734 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suzuki, K. Matsuo, K. Hirose, A. Hiraki, T. Kawase, M. Watanabe, T. Yamashita, H. Iwata, and K. Tajima One-carbon metabolism-related gene polymorphisms and risk of breast cancer Carcinogenesis, February 1, 2008; 29(2): 356 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho, M. Holmes, S. E. Hankinson, and W. C. Willett Nutrients Involved in One-Carbon Metabolism and Risk of Breast Cancer among Premenopausal Women Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2787 - 2790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Ericson, E. Sonestedt, B. Gullberg, H. Olsson, and E. Wirfalt High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort Am. J. Clinical Nutrition, August 1, 2007; 86(2): 434 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Stevens, M. L. McCullough, A. L. Pavluck, J. T. Talbot, H. S. Feigelson, M. J. Thun, and E. E. Calle Association of Polymorphisms in One-Carbon Metabolism Genes and Postmenopausal Breast Cancer Incidence Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1140 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Zhang, I-M. Lee, J. E. Manson, N. R. Cook, W. C. Willett, and J. E. Buring Alcohol Consumption and Breast Cancer Risk in the Women's Health Study Am. J. Epidemiol., March 15, 2007; 165(6): 667 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Larsson, E. Giovannucci, and A. Wolk Folate and Risk of Breast Cancer: A Meta-analysis J Natl Cancer Inst, January 3, 2007; 99(1): 64 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Lewis, R. M. Harbord, R. Harris, and G. D. Smith Meta-analyses of Observational and Genetic Association Studies of Folate Intakes or Levels and Breast Cancer Risk. J Natl Cancer Inst, November 15, 2006; 98(22): 1607 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Doyle, L. H. Kushi, T. Byers, K. S. Courneya, W. Demark-Wahnefried, B. Grant, A. McTiernan, C. L. Rock, C. Thompson, T. Gansler, et al. Nutrition and Physical Activity During and After Cancer Treatment: An American Cancer Society Guide for Informed Choices CA Cancer J Clin, November 1, 2006; 56(6): 323 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Chou, M.-H. Wu, J.-C. Yu, M.-S. Lee, T. Yang, H.-L. Shih, T.-Y. Wu, and C.-A. Sun Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan Carcinogenesis, November 1, 2006; 27(11): 2295 - 2300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. H. Kushi, T. Byers, C. Doyle, E. V. Bandera, M. McCullough, T. Gansler, K. S. Andrews, M. J. Thun, and The American Cancer Society 2006 Nutrition and Phy American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer With Healthy Food Choices and Physical Activity CA Cancer J Clin, September 1, 2006; 56(5): 254 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Larsson, E. Giovannucci, and A. Wolk Folate intake and stomach cancer incidence in a prospective cohort of Swedish women. Cancer Epidemiol. Biomarkers Prev., July 1, 2006; 15(7): 1409 - 1412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Stevens, C. Rodriguez, A. L. Pavluck, M. L. McCullough, M. J. Thun, and E. E. Calle Folate Nutrition and Prostate Cancer Incidence in a Large Cohort of US Men Am. J. Epidemiol., June 1, 2006; 163(11): 989 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Z Stolzenberg-Solomon, S.-C. Chang, M. F Leitzmann, K. A Johnson, C. Johnson, S. S Buys, R. N Hoover, and R. G Ziegler Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 895 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Larsson, N. Hakansson, E. Giovannucci, and A. Wolk Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men. J Natl Cancer Inst, March 15, 2006; 98(6): 407 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lajous, E. Lazcano-Ponce, M. Hernandez-Avila, W. Willett, and I. Romieu Folate, vitamin b6, and vitamin B12 intake and the risk of breast cancer among mexican women. Cancer Epidemiol. Biomarkers Prev., March 1, 2006; 15(3): 443 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Justenhoven, U. Hamann, C. B. Pierl, S. Rabstein, B. Pesch, V. Harth, C. Baisch, C. Vollmert, T. Illig, T. Bruning, et al. One-Carbon Metabolism and Breast Cancer Risk: No Association of MTHFR, MTR, and TYMS Polymorphisms in the GENICA Study from Germany Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 3015 - 3018. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Baglietto, D. R English, D. M Gertig, J. L Hopper, and G. G Giles Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study BMJ, October 8, 2005; 331(7520): 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kotsopoulos, A. Medline, R. Renlund, K.-J. Sohn, R. Martin, S. W. Hwang, S. Lu, M. C. Archer, and Y.-I. Kim Effects of dietary folate on the development and progression of mammary tumors in rats Carcinogenesis, September 1, 2005; 26(9): 1603 - 1612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Zhang, S. E. Hankinson, D. J. Hunter, E. L. Giovannucci, G. A. Colditz, and W. C. Willett Folate Intake and Risk of Breast Cancer Characterized by Hormone Receptor Status Cancer Epidemiol. Biomarkers Prev., August 1, 2005; 14(8): 2004 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dietrich, C. J.P. Brown, and G. Block The Effect of Folate Fortification of Cereal-Grain Products on Blood Folate Status, Dietary Folate Intake, and Dietary Folate Sources among Adult Non-Supplement Users in the United States J. Am. Coll. Nutr., August 1, 2005; 24(4): 266 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Emmons, A. M. Stoddard, R. Fletcher, C. Gutheil, E. G. Suarez, R. Lobb, J. Weeks, and J. A. Bigby Cancer Prevention Among Working Class, Multiethnic Adults: Results of the Healthy Directions-Health Centers Study Am J Public Health, July 1, 2005; 95(7): 1200 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, M. D. Gammon, W. Chan, C. Palomeque, J. G. Wetmur, G. C. Kabat, S. L. Teitelbaum, J. A. Britton, M. B. Terry, A. I. Neugut, et al. One-Carbon Metabolism, MTHFR Polymorphisms, and Risk of Breast Cancer Cancer Res., February 15, 2005; 65(4): 1606 - 1614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Le Marchand, C. A. Haiman, L. R. Wilkens, L. N. Kolonel, and B. E. Henderson MTHFR Polymorphisms, Diet, HRT, and Breast Cancer Risk: The Multiethnic Cohort Study Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2071 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Freudenheim, M. Bonner, S. Krishnan, C. B. Ambrosone, S. Graham, S. E. McCann, K. B. Moysich, E. Bowman, T. Nemoto, and P. G. Shields Diet and alcohol consumption in relation to p53 mutations in breast tumors Carcinogenesis, June 1, 2004; 25(6): 931 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Han, S. E. Hankinson, S. M. Zhang, I. De Vivo, and D. J. Hunter Interaction between Genetic Variations in DNA Repair Genes and Plasma Folate on Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., April 1, 2004; 13(4): 520 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Larsson, E. Giovannucci, and A. Wolk Dietary Folate Intake and Incidence of Ovarian Cancer: The Swedish Mammography Cohort J Natl Cancer Inst, March 3, 2004; 96(5): 396 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Shrubsole, Y.-T. Gao, Q. Cai, X. O. Shu, Q. Dai, J. R. Hebert, F. Jin, and W. Zheng MTHFR Polymorphisms, Dietary Folate Intake, and Breast Cancer Risk: Results from the Shanghai Breast Cancer Study Cancer Epidemiol. Biomarkers Prev., February 1, 2004; 13(2): 190 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Bailey Folate, Methyl-Related Nutrients, Alcohol, and the MTHFR 677C->T Polymorphism Affect Cancer Risk: Intake Recommendations J. Nutr., November 1, 2003; 133(11): 3748S - 3753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jiang, F. B. Hu, E. L. Giovannucci, E. B. Rimm, M. J. Stampfer, D. Spiegelman, B. A. Rosner, and W. C. Willett Joint Association of Alcohol and Folate Intake with Risk of Major Chronic Disease in Women Am. J. Epidemiol., October 15, 2003; 158(8): 760 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Brown, T. Byers, C. Doyle, K. S. Courneya, W. Demark-Wahnefried, L. H. Kushi, A. McTiernan, C. L. Rock, N. Aziz, A. S. Bloch, et al. Nutrition and Physical Activity During and After Cancer Treatment: An American Cancer Society Guide for Informed Choices CA Cancer J Clin, September 1, 2003; 53(5): 268 - 291. [Abstract] [Full Text]
|
|
|
|
|
|
E. Cho, D. Spiegelman, D. J. Hunter, W. Y. Chen, S. M. Zhang, G. A. Colditz, and W. C. Willett Premenopausal Intakes of Vitamins A, C, and E, Folate, and Carotenoids, and Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., August 1, 2003; 12(8): 713 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Bailey, G. C. Rampersaud, and G. P. A. Kauwell Folic Acid Supplements and Fortification Affect the Risk for Neural Tube Defects, Vascular Disease and Cancer: Evolving Science, J. Nutr., June 1, 2003; 133(6): 1961S - 1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kotsopoulos, K.-J. Sohn, R. Martin, M. Choi, R. Renlund, C. Mckerlie, S. W. Hwang, A. Medline, and Y.-I. J. Kim Dietary folate deficiency suppresses N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats Carcinogenesis, May 1, 2003; 24(5): 937 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Zhang, W. C. Willett, J. Selhub, D. J. Hunter, E. L. Giovannucci, M. D. Holmes, G. A. Colditz, and S. E. Hankinson Plasma Folate, Vitamin B6, Vitamin B12, Homocysteine, and Risk of Breast Cancer J Natl Cancer Inst, March 5, 2003; 95(5): 373 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Feigelson, C. R. Jonas, A. S. Robertson, M. L. McCullough, M. J. Thun, and E. E. Calle Alcohol, Folate, Methionine, and Risk of Incident Breast Cancer in the American Cancer Society Cancer Prevention Study II Nutrition Cohort Cancer Epidemiol. Biomarkers Prev., February 1, 2003; 12(2): 161 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Rampersaud, G. P.A. Kauwell, and L. B. Bailey Folate: A Key to Optimizing Health and Reducing Disease Risk in the Elderly J. Am. Coll. Nutr., February 1, 2003; 22(1): 1 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Sellers, R. A. Vierkant, J. R. Cerhan, S. M. Gapstur, C. M. Vachon, J. E. Olson, V. S. Pankratz, L. H. Kushi, and A. R. Folsom Interaction of Dietary Folate Intake, Alcohol, and Risk of Hormone Receptor-defined Breast Cancer in a Prospective Study of Postmenopausal Women Cancer Epidemiol. Biomarkers Prev., October 1, 2002; 11(10): 1104 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Fairfield and R. H. Fletcher Vitamins for Chronic Disease Prevention in Adults: Scientific Review JAMA, June 19, 2002; 287(23): 3116 - 3126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Willett and M. J. Stampfer What Vitamins Should I Be Taking, Doctor? N. Engl. J. Med., December 20, 2001; 345(25): 1819 - 1824. [Full Text] [PDF]
|
|
|
|
|
|
K. W. Singletary and S. M. Gapstur Alcohol and Breast Cancer: Review of Epidemiologic and Experimental Evidence and Potential Mechanisms JAMA, November 7, 2001; 286(17): 2143 - 2151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kropp, H. Becher, A. Nieters, and J. Chang-Claude Low-to-Moderate Alcohol Consumption and Breast Cancer Risk by Age 50 Years among Women in Germany Am. J. Epidemiol., October 1, 2001; 154(7): 624 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Shrubsole, F. Jin, Q. Dai, X.-O. Shu, J. D. Potter, J. R. Hebert, Y.-T. Gao, and W. Zheng Dietary Folate Intake and Breast Cancer Risk: Results from the Shanghai Breast Cancer Study Cancer Res., October 1, 2001; 61(19): 7136 - 7141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Goodman, J. A. Lavigne, K. Wu, K. J. Helzlsouer, P. T. Strickland, J. Selhub, and J. D. Yager COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk Carcinogenesis, October 1, 2001; 22(10): 1661 - 1665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. C. Willett Diet and Cancer: One View at the Start of the Millennium Cancer Epidemiol. Biomarkers Prev., January 1, 2001; 10(1): 3 - 8. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Ulrich, J. Bigler, C. M. Velicer, E. A. Greene, F. M. Farin, and J. D. Potter Searching Expressed Sequence Tag Databases: Discovery and Confirmation of a Common Polymorphism in the Thymidylate Synthase Gene Cancer Epidemiol. Biomarkers Prev., December 1, 2000; 9(12): 1381 - 1385. [Abstract] [Full Text]
|
|
|
|
|
|
E. Negri, C. La Vecchia, and S. Franceschi Re: Dietary Folate Consumption and Breast Cancer Risk J Natl Cancer Inst, August 2, 2000; 92(15): 1270a - 1271a. [Full Text] [PDF]
|
|