© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 24, 2037-2039,
December 20, 2000
© 2000 Oxford University Press
BRIEF COMMUNICATION |
Hereditary Retinoblastoma and Risk of Lung Cancer
Affiliations of authors: R. A. Kleinerman, R. E. Tarone, M. A. Tucker, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; D. H. Abramson, New York Presbyterian Hospital–Cornell Medical Center, New York, NY; J. M. Seddon, Massachusetts Eye and Ear Infirmary, Boston; F. P. Li, Division of Cancer Epidemiology and Control, Dana-Farber Cancer Institute, and Harvard School of Public Health, Boston.
Correspondence to: Ruth A. Kleinerman, M.P.H., National Institutes of Health, Executive Plaza South, Rm. 7044, Bethesda, MD 20892 (e-mail: Kleinerr@exchange.nih.gov).
Patients who have survived hereditary retinoblastoma are at increased risk of dying of a sarcoma, a melanoma, or a brain tumor. The increased risk has been attributed to germline mutations in the retinoblastoma-1 (RB1) gene, which encodes the cell cycle regulatory protein pRb (1). However, the extent to which patients with hereditary retinoblastoma are at increased risk of dying of common epithelial cancers of adulthood, such as lung cancer, is unknown. Somatic mutations in the RB1 gene are known to contribute to the development of lung cancer (2,3), and evidence of increased risk of lung cancer in adult RB1 mutation carriers has been reported (4,5), but questions remain about the association between hereditary retinoblastoma and lung cancer risk (6). In our earlier follow-up studies of 1604 one-year survivors of retinoblastoma (1,7) followed for a
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