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JNCI Journal of the National Cancer Institute 2000 92(24):1976-1977; doi:10.1093/jnci/92.24.1976
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 24, 1976-1977, December 20, 2000
© 2000 Oxford University Press

NEWS

Can We Predict Response to 5-FU?

Jean McCann

It may now be possible to predict which patients with colorectal cancer will respond to treatment with 5-fluorouracil alone or in combination for colorectal cancer, it may be possible to predict if patients will respond to treatment.

Patrick Johnston, M.D., of the University of Belfast, claims that by using just two molecular markers—high thymidylate synthase (TS) levels, and mutant p53—"you can basically predict 100% of patients that will not respond to fluoropyrmidines." TS is the . . . [Full Text of this Article]


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