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JNCI Journal of the National Cancer Institute 2000 92(23):1949; doi:10.1093/jnci/92.23.1949-a
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 23, 1949, December 6, 2000
© 2000 Oxford University Press

CORRESPONDENCE

RESPONSE: More About: Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

Andrew G. Renehan, Sarah T. O'Dwyer, Stephen M. Shalet

Affiliations of authors: A. G. Renehan, S. T. O'Dwyer (Department of Surgery), S. M. Shalet (Department of Endocrinology), Christie Hospital National Health Service Trust, Manchester, U.K.

Correspondence to: Andrew G. Renehan, F.R.C.S., F.D.S., Department of Surgery, Christie Hospital National Health Service Trust, Wilmslow Rd., Manchester M20 4BX, U.K. (e-mail: arenehan@picr.man.ac.uk).

The IGFs are multifunctional regulatory peptides with characteristics of both classic "endocrine" hormones and tissue growth factors. There is considerable interindividual variation in circulating levels of IGF-I and its main binding protein, IGFBP-3, and it is postulated that this heterogeneity of IGF physiology may determine cancer risk. A number of recent prospective and case–control studies [reviewed in (1)] have supported this hypothesis for many common malignancies, including colorectal . . . [Full Text of this Article]

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