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JNCI Journal of the National Cancer Institute 2000 92(23):1947-1948; doi:10.1093/jnci/92.23.1947-a
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 23, 1947-1948, December 6, 2000
© 2000 Oxford University Press

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More About: Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

Adrienne C. Paterson, Kerri S. Leeding, Leon A. Bach, Graham S. Baldwin, Finlay A. Macrae, Arthur Shulkes

Affiliations of authors: A. C. Paterson, G. S. Baldwin, A. Shulkes (Department of Surgery), K. S. Leeding, L. A. Bach (Department of Medicine), Austin and Repatriation Medical Centre, University of Melbourne, Australia; F. A. Macrae, Department of Gastroenterology, The Royal Melbourne Hospital.

Correspondence to: Professor Arthur Shulkes, D.Sc., Department of Surgery, Austin and Repatriation Medical Centre, University of Melbourne, Vic 3084, Australia (e-mail: aas@unimelb.edu.au).

Several recent epidemiologic studies (1–5) have implicated high levels of insulin-like growth factor-I (IGF-I) in plasma as a risk factor for prostate, breast, and colorectal cancers. The biologic evidence in favor of an important role for IGF-I in the development of colorectal and other cancers is strong (1,3,4). IGF-I stimulates transformation and inhibits apoptosis, IGF-I . . . [Full Text of this Article]

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