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JNCI Journal of the National Cancer Institute 2000 92(2):89; doi:10.1093/jnci/92.2.89B
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 2, 89B-89b, January 19, 2000
© 2000 Oxford University Press

MEMORANDUM FOR: Science Writers and Editors on the Journal Press List

BCAR1/p130Cas Gene Is Involved in Tamoxifen Resistance Seen in Breast Cancer

January 13, 2000 (EMBARGOED FOR RELEASE 4 P.M. EST January 18)

Katherine Arnold, Deputy News Editor, Dan Eckstein, (301) 986-1891, ext. 112

A gene involved in the tamoxifen resistance seen in many breast cancer patients has been identified, and high levels of its expression in breast cancer patients have been associated with more rapid disease recurrence and increased resistance to tamoxifen therapy. About half of tumors that are estrogen receptor (ER) positive do not respond to tamoxifen, and almost all breast tumors . . . [Full Text of this Article]


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