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JNCI Journal of the National Cancer Institute 2000 92(14):1185; doi:10.1093/jnci/92.14.1185
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 14, 1185, July 19, 2000
© 2000 Oxford University Press

CORRESPONDENCE

RESPONSE: Re: Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

Adrian M. Senderowicz, Edward A. Sausville

Affiliations of authors: A. M. Senderowicz, Molecular Therapeutics Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD; E. A. Sausville, Clinical Trials Unit, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD.

Correspondence to: Adrian M. Senderoewicz, M.D., National Institutes of Health, Bldg. 30, Rm. 211, Bethesda, MD 20892–4340 (e-mail: sendero@helix.nih.gov).

Dr. Darzynkiewicz's strategy to use signal transduction and cell cycle modulators to protect normal cells from cytotoxic agents sounds very attractive, at first. Certainly, inhibitors that specifically modulate only signals important for the "Rb [retinoblastoma] . . . [Full Text of this Article]

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