© 2000 by Oxford University Press
Journal of the National Cancer Institute, Vol. 92, No. 14, 1182A-1183,
July 19, 2000
© 2000 Oxford University Press
CORRESPONDENCE |
RESPONSE: Re: Clonal Expansion and Loss of Heterozygosity at Chromosomes 9p and 17p in Premalignant Esophageal (Barrett's) Tissue
Correspondence to: Brian J. Reid, M.D., Ph.D., Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 (e-mail: bjr@fhcrc.org).
We appreciate the comments of Walch et al. concerning the differences between our respective studies. Both groups used objective methods (comparative genomic hybridization [CGH] versus fluorescent loss of heterozygosity analysis) to assess somatic genetic abnormalities in Barrett's esophagus. Both groups provided similar data that progression is associated with nonlinear evolution of neoplastic cell lineages leading
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