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JNCI Journal of the National Cancer Institute 2000 92(10):840-841; doi:10.1093/jnci/92.10.840
© 2000 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 92, No. 10, 840-841, May 17, 2000
© 2000 Oxford University Press

BRIEF COMMUNICATION

Risk of Breast Cancer in Prematurely Born Women

Anders Ekbom, Gunnar Erlandsson, Chung-cheng Hsieh, Dimitrios Trichopoulos, Hans-Olov Adami, Sven Cnattingius

Affiliations of authors: A. Ekbom, H.-O. Adami, Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden, and Department of Epidemiology, Harvard School of Public Health, Boston, MA; G. Erlandsson, Department of Medical Epidemiology, Karolinska Institutet; C.-c. Hsieh, Department of Epidemiology, Harvard School of Public Health, and Cancer Center, University of Massachusetts Medical Center, Worcester; D. Trichopoulos, Department of Epidemiology, Harvard School of Public Health; S. Cnattingius, Department of Medical Epidemiology, Karolinska Institutet.

Correspondence to: Anders Ekbom, M.D., Ph.D., Department of Medical Epidemiology, P.O. Box 281, Karolinska Institutet, SE-171 77 Stockholm, Sweden (e-mail: Anders.Ekbom@mep.ki.se).

Epidemiologic studies of breast cancer [reviewed in (1)] have for several decades focused on the role of reproductive factors during adult life. A new line of research opened when it was suggested that perinatal events and conditions may influence a woman's breast cancer risk throughout her life (2,3). Five separate epidemiologic studies (4–8) have tested this hypothesis. Besides a weak association between increasing birth weight and increased risk for breast cancer [seen in four studies (4–7)], most pronounced in women with premenopausal breast cancer, two studies (4,7) also demonstrated an inverse association between preeclampsia during pregnancy and breast cancer in the offspring out of . . . [Full Text of this Article]

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