© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 7, 605-613,
April 7, 1999
© 1999 Oxford University Press
Fruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort
Affiliations of authors: D. S. Michaud (Department of Nutrition), D. Spiegelman (Departments of Epidemiology and Biostatistics), Harvard School of Public Health, Boston, MA; S. K. Clinton, The Arthur G. James Cancer Hospital and Research Institute, Ohio State University, Columbus; E. B. Rimm, W. C. Willett, Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston; E. L. Giovannucci, Department of Nutrition, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital.
Correspondence to: Dominique S. Michaud, Sc.D., Department of Nutrition, Harvard School of Public Health, Boston, MA 02115 (e-mail: hpdsm{at}gauss.bwh.harvard.edu).
BACKGROUND: Previous epidemiologic studies of fruit and vegetable intake and bladder cancer risk have yielded inconsistent results, especially with regard to the types of fruits and vegetables consumed. We examined total fruit and vegetable intake, as well as intakes of subtypes of fruits and vegetables, in relation to bladder cancer risk in a large male prospective cohort study. METHODS: Two hundred fifty-two cases of incident bladder cancer were diagnosed from 1986 through January 31, 1996, among 47 909 men enrolled in the Health Professionals Follow-up Study. Each participant in this cohort completed a 131-item food-frequency questionnaire in 1986 and subsequently in 1990 and 1994. We used logistic regression analyses to examine fruit and vegetable intake in relation to bladder cancer risk, after adjusting for age, history of cigarette smoking, current smoking status, geographic region, total fluid intake, and caloric intake. RESULTS: We observed a weak, inverse association that was not statistically significant between total fruit and vegetable intake and bladder cancer risk. Intake of cruciferous vegetables was inversely associated with risk (relative risk = 0.49; 95% confidence interval = 0.32-0.75, for the highest category of cruciferous vegetable intake compared with the lowest), but intakes of yellow or green leafy vegetables or carotenoid-rich vegetables were not associated with risk. Individual cruciferous vegetables, except for coleslaw, were all inversely related to bladder cancer risk, but only the associations for broccoli and cabbage were statistically significant. CONCLUSIONS: Data from this study indicate that high cruciferous vegetable consumption may reduce bladder cancer risk, but other vegetables and fruits may not confer appreciable benefits against this cancer.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. E. Bekkering, R. J. Harris, S. Thomas, A.-M. B. Mayer, R. Beynon, A. R. Ness, R. M. Harbord, C. Bain, G. D. Smith, and J. A. C. Sterne How Much of the Data Published in Observational Studies of the Association between Diet and Prostate or Bladder Cancer Is Usable for Meta-Analysis? Am. J. Epidemiol., May 1, 2008; 167(9): 1017 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tang, G. R. Zirpoli, K. Guru, K. B. Moysich, Y. Zhang, C. B. Ambrosone, and S. E. McCann Consumption of Raw Cruciferous Vegetables is Inversely Associated with Bladder Cancer Risk Cancer Epidemiol. Biomarkers Prev., April 1, 2008; 17(4): 938 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-A. Lee, J. H Fowke, W. Lu, C. Ye, Y. Zheng, Q. Cai, K. Gu, Y.-T. Gao, X.-o. Shu, and W. Zheng Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk Am. J. Clinical Nutrition, March 1, 2008; 87(3): 753 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Munday, P. Mhawech-Fauceglia, C. M. Munday, J. D. Paonessa, L. Tang, J. S. Munday, C. Lister, P. Wilson, J. W. Fahey, W. Davis, et al. Inhibition of Urinary Bladder Carcinogenesis by Broccoli Sprouts Cancer Res., March 1, 2008; 68(5): 1593 - 1600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Benetou, P. Orfanos, P. Lagiou, D. Trichopoulos, P. Boffetta, and A. Trichopoulou Vegetables and Fruits in Relation to Cancer Risk: Evidence from the Greek EPIC Cohort Study Cancer Epidemiol. Biomarkers Prev., February 1, 2008; 17(2): 387 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sacerdote, G. Matullo, S. Polidoro, S. Gamberini, A. Piazza, M. R. Karagas, L. Rolle, P. De Stefanis, G. Casetta, F. Morabito, et al. Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer Mutagenesis, July 1, 2007; 22(4): 281 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Fowke, J. D. Morrow, S. Motley, R. M. Bostick, and R. M. Ness Brassica vegetable consumption reduces urinary F2-isoprostane levels independent of micronutrient intake Carcinogenesis, October 1, 2006; 27(10): 2096 - 2102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Thomson, K. K. Brown, J. M. Pullar, and M. B. Hampton Phenethyl Isothiocyanate Triggers Apoptosis in Jurkat Cells Made Resistant by the Overexpression of Bcl-2. Cancer Res., July 1, 2006; 66(13): 6772 - 6777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Ambrosone Epidemiological evidence for chemopreventive effects of cruciferous vegetables on cancer risk. AACR Meeting Abstracts, April 1, 2006; 2006(1): 1365 - 1365. [Abstract]
|
|
|
|
|
|
M. McGrath, D. S. Michaud, and I. De Vivo Hormonal and Reproductive Factors and the Risk of Bladder Cancer in Women Am. J. Epidemiol., February 1, 2006; 163(3): 236 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mori, A. Koide, K. Tatematsu, S. Sugie, and H. Mori Effects of {alpha}-naphthyl isothiocyanate and a heterocyclic amine, PhIP, on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver Mutagenesis, January 1, 2005; 20(1): 15 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-C. Hung, K. J. Joshipura, R. Jiang, F. B. Hu, D. Hunter, S. A. Smith-Warner, G. A. Colditz, B. Rosner, D. Spiegelman, and W. C. Willett Fruit and Vegetable Intake and Risk of Major Chronic Disease J Natl Cancer Inst, November 3, 2004; 96(21): 1577 - 1584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tang and Y. Zhang Dietary Isothiocyanates Inhibit the Growth of Human Bladder Carcinoma Cells J. Nutr., August 1, 2004; 134(8): 2004 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-S. Keck and J. W. Finley Cruciferous Vegetables: Cancer Protective Mechanisms of Glucosinolate Hydrolysis Products and Selenium Integr Cancer Ther, March 1, 2004; 3(1): 5 - 12. [Abstract] [PDF]
|
|
|
|
|
|
E. Giovannucci, E. B. Rimm, Y. Liu, M. J. Stampfer, and W. C. Willett A Prospective Study of Cruciferous Vegetables and Prostate Cancer Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1403 - 1409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Fowke, X.-O. Shu, Q. Dai, A. Shintani, C. C. Conaway, F.-L. Chung, Q. Cai, Y.-T. Gao, and W. Zheng Urinary Isothiocyanate Excretion, Brassica Consumption, and Gene Polymorphisms among Women Living in Shanghai, China Cancer Epidemiol. Biomarkers Prev., December 1, 2003; 12(12): 1536 - 1539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Riboli and T. Norat Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk Am. J. Clinical Nutrition, September 1, 2003; 78(3): 559S - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Fowke, F.-L. Chung, F. Jin, D. Qi, Q. Cai, C. Conaway, J.-R. Cheng, X.-O. Shu, Y.-T. Gao, and W. Zheng Urinary Isothiocyanate Levels, Brassica, and Human Breast Cancer Cancer Res., July 15, 2003; 63(14): 3980 - 3986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L McCullough, D. Feskanich, M. J Stampfer, E. L Giovannucci, E. B Rimm, F. B Hu, D. Spiegelman, D. J Hunter, G. A Colditz, and W. C Willett Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance Am. J. Clinical Nutrition, December 1, 2002; 76(6): 1261 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Jacobs, A. K. Henion, P. J. Briggs, C. J. Connell, M. L. McCullough, C. R. Jonas, C. Rodriguez, E. E. Calle, and M. J. Thun Vitamin C and Vitamin E Supplement Use and Bladder Cancer Mortality in a Large Cohort of US Men and Women Am. J. Epidemiol., December 1, 2002; 156(11): 1002 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Airoldi, F. Orsi, C. Magagnotti, R. Coda, D. Randone, G. Casetta, M. Peluso, A. Hautefeuille, C. Malaveille, and P. Vineis Determinants of 4-aminobiphenyl-DNA adducts in bladder cancer biopsies Carcinogenesis, May 1, 2002; 23(5): 861 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. A. Zeegers, R. A. Goldbohm, and P. A. van den Brandt Consumption of Vegetables and Fruits and Urothelial Cancer Incidence: a Prospective Study Cancer Epidemiol. Biomarkers Prev., November 1, 2001; 10(11): 1121 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Talalay and J. W. Fahey Phytochemicals from Cruciferous Plants Protect against Cancer by Modulating Carcinogen Metabolism J. Nutr., November 1, 2001; 131(11): 3027S - 3033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Shapiro, J. W. Fahey, K. L. Wade, K. K. Stephenson, and P. Talalay Chemoprotective Glucosinolates and Isothiocyanates of Broccoli Sprouts: Metabolism and Excretion in Humans Cancer Epidemiol. Biomarkers Prev., May 1, 2001; 10(5): 501 - 508. [Abstract] [Full Text]
|
|
|
|
|
|
D. S. Michaud, D. Spiegelman, S. K. Clinton, E. B. Rimm, W. C. Willett, and E. Giovannucci Prospective Study of Dietary Supplements, Macronutrients, Micronutrients, and Risk of Bladder Cancer in US Men Am. J. Epidemiol., December 15, 2000; 152(12): 1145 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Johnston, C. A. Taylor, and J. S Hampl More Americans Are Eating "5 A Day" but Intakes of Dark Green and Cruciferous Vegetables Remain Low J. Nutr., December 1, 2000; 130(12): 3063 - 3067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-J. Su, T.-M. Yeh, H.-Y. Lei, and N.-H. Chow The Potential of Soybean Foods as a Chemoprevention Approach for Human Urinary Tract Cancer Clin. Cancer Res., January 1, 2000; 6(1): 230 - 236. [Abstract] [Full Text]
|
|