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JNCI Journal of the National Cancer Institute 1999 91(22):1965-1967; doi:10.1093/jnci/91.22.1965
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 22, 1965-1967, November 17, 1999
© 1999 Oxford University Press

BRIEF COMMUNICATION

Insulin-Like Growth Factor-Binding Protein-1 and Prostate Cancer

Lisa B. Signorello, Kerstin Brismar, Reinhold Bergstrom, Swen-Olof Andersson, Alicja Wolk, Dimitrios Trichopoulos, Hans-Olov Adami

Affiliations of authors: L. B. Signorello, Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden, and International Epidemiology Institute, Rockville, MD; K. Brismar, Department of Molecular Medicine, The Endocrine and Diabetes Unit, Karolinska Hospital, Stockholm; R. Bergstrom (deceased June 1999), Department of Medical Epidemiology, Karolinska Institute, and Department of Statistics, Uppsala University, Sweden; S.-O Andersson, Department of Urology, Orebro Medical Center, Sweden; A. Wolk, Department of Medical Epidemiology, Karolinska Institute; D. Trichopoulos, Department of Epidemiology and the Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA; H.-O. Adami, Department of Medical Epidemiology, Karolinska Institute, and Department of Epidemiology and the Harvard Center for Cancer Prevention, Harvard School of Public Health.

Correspondence to: Lisa B. Signorello, Sc.D., International Epidemiology Institute, 1455 Research Blvd., Suite 5082, Rockville, MD 20850 (e-mail: lbsignore@aol.com).

There is growing and persuasive evidence, both experimental (1-4) and epidemiologic (5-7), that the peptide hormone insulin-like growth factor-I (IGF-I) is a critical factor in the development of prostate cancer. Because of their central role in the regulation of bioavailable IGF-I, the insulin-like growth factor-binding proteins (IGFBPs) have also come under scrutiny as potential mediators of prostate cancer risk (8-12). There is considerable disagreement concerning which, if any, of the IGFBPs are relevant to the development of prostate cancer. Epidemiologically, IGFBP-3 has been examined (5,7), primarily because more than 95% of circulating IGF-I is bound to this protein (13) together with an acid labile subunit (ALS, a protein . . . [Full Text of this Article]

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