Skip Navigation

JNCI Journal of the National Cancer Institute 1999 91(22):1910-1911; doi:10.1093/jnci/91.22.1910
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Dritschilo, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dritschilo, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 91, No. 22, 1910-1911, November 17, 1999
© 1999 Oxford University Press

EDITORIALS

Radiosensitivity and Transcription Factor NF-{kappa}B Inhibition—Progress and Pitfalls

Anatoly Dritschilo

Correspondence to: Anatoly Dritschilo, M.D., Department of Radiation Medicine, Georgetown University Medical Center, TRB E202A-B, 3970 Reservoir Rd., N.W., Washington, DC 20007 (e-mail: dritscha@gunet.georgetown.edu).

Cellular responses to ionizing radiation include activation of signal transduction cascades that may originate at the plasma membrane, cytoplasm, or nucleus. The cell's success in dealing with radiation "stress" determines its survival or death. Activation of transcription factor NF-{kappa}B, an immediate early response after exposure to ionizing radiations, functions to protect cells from apoptosis (programmed cell death), but the role of NF-{kappa}B in mitotic cell death has not been fully defined (1,2). NF-{kappa}B is constitutively activated in lymphoid cells, immortal ataxia telangiectasia (AT) fibroblasts, and other cells (3-. . . [Full Text of this Article]

REFERENCES


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
A. Munshi, J. F. Kurland, T. Nishikawa, P. J. Chiao, M. Andreeff, and R. E. Meyn
Inhibition of constitutively activated nuclear factor-{kappa}B radiosensitizes human melanoma cells
Mol. Cancer Ther., August 1, 2004; 3(8): 985 - 992.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. M. Kim, Y. Zhang, B.-Y. Kim, S. J. Jeong, S. A. Lee, G.-D. Kim, A. Dritschilo, and M. Jung
The p65 subunit of nuclear factor-{kappa}B is a molecular target for radiation sensitization of human squamous carcinoma cells
Mol. Cancer Ther., June 1, 2004; 3(6): 693 - 698.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. G. Hillman, J. D. Forman, O. Kucuk, M. Yudelev, R. L. Maughan, J. Rubio, A. Layer, S. Tekyi-Mensah, J. Abrams, and F. H. Sarkar
Genistein Potentiates the Radiation Effect on Prostate Carcinoma Cells
Clin. Cancer Res., February 1, 2001; 7(2): 382 - 390.
[Abstract] [Full Text]