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JNCI Journal of the National Cancer Institute 1999 91(21):1789; doi:10.1093/jnci/91.21.1789
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 21, 1789, November 3, 1999
© 1999 Oxford University Press


IN THIS ISSUE

Risks and Benefits of Tamoxifen Therapy

Tamoxifen treatment has been shown in a randomized placebo-controlled trial to reduce substantially the risk of invasive breast cancer in a population of women at elevated risk. However, tamoxifen treatment is associated with some health-related risks, e.g., endometrial cancer, stroke, pulmonary embolism, and deep vein thrombosis. Gail et al. (p. 1829) have developed tools to assist in counseling women about the use of tamoxifen and in weighing the risks and benefits of treatment with this drug. They find that the risks and benefits of tamoxifen depend on age and race, as well as on a woman's specific . . . [Full Text of this Article]

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