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JNCI Journal of the National Cancer Institute 1999 91(20):1773-1775; doi:10.1093/jnci/91.20.1773
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 20, 1773-1775, October 20, 1999
© 1999 Oxford University Press

BRIEF COMMUNICATION

Risk of Transfusion-Associated Transmission of Human Herpesvirus 8

Eric A. Engels, Helen Eastman, Dharam V. Ablashi, Rainford J. Wilks, Joy Braham, Angela Manns

Affiliations of authors: E. A. Engels, A. Manns, Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; H. Eastman, D. V. Ablashi, Advanced Biotechnologies, Inc., Columbia, MD; R. J. Wilks, J. Braham, Tropical Metabolism Research Unit and Department of Pathology, University of the West Indies, Kingston, Jamaica.

Correspondence to: Eric A. Engels, M.D., M.P.H., National Institutes of Health, 6120 Executive Blvd., MSC 7248, Bethesda, MD 20822 (e-mail: engelse@exchange.nih.gov).

Human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma herpesvirus, causes Kaposi's sarcoma (1) and is associated with body cavity-based lymphomas and multicentric Castleman's disease (2,3). HHV8 is spread sexually (4,5), but other routes of transmission probably exist because, in some cases, infection has been shown to be acquired in childhood in HHV8-endemic areas, such as Mediterranean Europe and sub-Saharan Africa (6-8).

An unresolved question with public health implications is whether blood transfusions can transmit HHV8. HHV8 can be identified in circulating lymphocytes from healthy blood donors (9,10), although the proportion of infected donors with viremia is unknown. Cytomegalovirus, another cell-associated herpesvirus, is readily transmitted via blood transfusion (. . . [Full Text of this Article]

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