© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 20, 1738-1743,
October 20, 1999
© 1999 Oxford University Press
REPORTS |
Serum 
-Tocopherol and Subsequent Risk of Lung Cancer Among Male Smokers
Affiliations of authors: K. Woodson, J. A. Tangrea, P. R. Taylor, D. Albanes, Cancer Prevention Studies Branch, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD; M. J. Barrett, Information Management Services, Inc., Silver Spring, MD; J. Virtamo, National Public Health Institute, Helsinki, Finland.
Correspondence to: Karen Woodson, Ph.D., M.P.H., National Institutes of Health, 6006 Executive Blvd. MSC 7058, Bethesda, MD 20892-7058.
BACKGROUND: Higher blood levels of 
-tocopherol, the predominant form of vitamin E,
have been associated in some studies with a reduced risk of lung cancer, but other studies have
yielded conflicting results. To clarify this association, we examined the relationship between
prospectively collected serum -tocopherol and lung cancer in the Alpha-Tocopherol,
Beta-Carotene Cancer Prevention (ATBC) Study cohort. METHODS: The ATBC Study was a
randomized, clinical trial of 29 133 white male smokers from Finland who were 50-69
years old and who had received -tocopherol (50 mg), ß-carotene (20 mg), both, or
neither daily for 5-8 years. Data regarding medical histories, smoking, and dietary factors were
obtained at study entry, as was a serum specimen for baseline -tocopherol determination.
-Tocopherol measurements were available for 29 102 of the men, among whom
1144 incident cases of lung cancer were diagnosed during a median observation period of 7.7
years. The association between -tocopherol and lung cancer was evaluated with the use of
multivariate proportional hazards regression. RESULTS: A 19% reduction in lung cancer
incidence was observed in the highest versus lowest quintile of serum -tocopherol (relative
risk = 0.81; 95% confidence interval = 0.67-0.97). There was a stronger
inverse association among younger men (<60 years), among men with less cumulative tobacco
exposure (<40 years of smoking), and possibly among men receiving -tocopherol
supplementation. CONCLUSIONS: In the ATBC Study cohort, higher serum -tocopherol
status is associated with lower lung cancer risk; this relationship appears stronger among younger
persons and among those with less cumulative smoke exposure. These findings suggest that high
levels of -tocopherol, if present during the early critical stages of tumorigenesis, may inhibit
lung cancer development.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. M. Penning and C. Lerman Genomics of Smoking Exposure and Cessation: Lessons for Cancer Prevention and Treatment Cancer Prevention Research, July 1, 2008; 1(2): 80 - 83. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Khurana, H. R. Bejjanki, G. Caldito, and M. W. Owens Statins Reduce the Risk of Lung Cancer in Humans: A Large Case-Control Study of US Veterans Chest, May 1, 2007; 131(5): 1282 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rohrmann, J. Linseisen, H. C. Boshuizen, J. Whittaker, A. Agudo, P. Vineis, P. Boffetta, M. K. Jensen, A. Olsen, K. Overvad, et al. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Am. J. Epidemiol., December 1, 2006; 164(11): 1103 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 The HOPE and HOPE-TOO Trial Investigators Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial JAMA, March 16, 2005; 293(11): 1338 - 1347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Han, D. D. Liu, J. J. Lee, J. Kurie, R. Lotan, W. K. Hong, and H.-Y. Lee 9-cis-Retinoic Acid Treatment Increases Serum Concentrations of {alpha}-Tocopherol in Former Smokers Clin. Cancer Res., March 15, 2005; 11(6): 2305 - 2311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Lippman, P. J. Goodman, E. A. Klein, H. L. Parnes, I. M. Thompson, A. R. Kristal, R. M. Santella, J. L. Probstfield, C. M. Moinpour, D. Albanes, et al. Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT) J Natl Cancer Inst, January 19, 2005; 97(2): 94 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Venkateswaran, N. E. Fleshner, L. M. Sugar, and L. H. Klotz Antioxidants Block Prostate Cancer in Lady Transgenic Mice Cancer Res., August 15, 2004; 64(16): 5891 - 5896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Wright, S. T. Mayne, R. Z. Stolzenberg-Solomon, Z. Li, P. Pietinen, P. R. Taylor, J. Virtamo, and D. Albanes Development of a Comprehensive Dietary Antioxidant Index and Application to Lung Cancer Risk in a Cohort of Male Smokers Am. J. Epidemiol., July 1, 2004; 160(1): 68 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Winterhalder, F. R. Hirsch, G. K. Kotantoulas, W. A. Franklin, and P. A. Bunn Jr Chemoprevention of lung cancer--from biology to clinical reality Ann. Onc., February 1, 2004; 15(2): 185 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Yuan, D. O. Stram, K. Arakawa, H.-P. Lee, and M. C. Yu Dietary Cryptoxanthin and Reduced Risk of Lung Cancer: The Singapore Chinese Health Study Cancer Epidemiol. Biomarkers Prev., September 1, 2003; 12(9): 890 - 898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Goodman, S. Schaffer, G. S. Omenn, C. Chen, and I. King The Association between Lung and Prostate Cancer Risk, and Serum Micronutrients: Results and Lessons Learned from {beta}-Carotene and Retinol Efficacy Trial Cancer Epidemiol. Biomarkers Prev., June 1, 2003; 12(6): 518 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Djousse, J. F. Dorgan, Y. Zhang, A. Schatzkin, M. Hood, R. B. D'Agostino, D. L. Copenhafer, B. E. Kreger, and R. C. Ellison Alcohol Consumption and Risk of Lung Cancer: The Framingham Study J Natl Cancer Inst, December 18, 2002; 94(24): 1877 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Lippman and M. R. Spitz Lung Cancer Chemoprevention: An Integrated Approach J. Clin. Oncol., September 15, 2001; 19(90001): 74s - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Yuan, R. K. Ross, X.-D. Chu, Y.-T. Gao, and M. C. Yu Prediagnostic Levels of Serum {beta}-Cryptoxanthin and Retinol Predict Smoking-related Lung Cancer Risk in Shanghai, China Cancer Epidemiol. Biomarkers Prev., July 1, 2001; 10(7): 767 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Wallstrom, E. Wirfalt, P. H Lahmann, B. Gullberg, L. Janzon, and G. Berglund Serum concentrations of {beta}-carotene and {{alpha}}-tocopherol are associated with diet, smoking, and general and central adiposity Am. J. Clinical Nutrition, April 1, 2001; 73(4): 777 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Sandhu, A. S. Haqqani, and H. C. Birnboim Effect of Dietary Vitamin E on Spontaneous or Nitric Oxide Donor-Induced Mutations in a Mouse Tumor Model J Natl Cancer Inst, September 6, 2000; 92(17): 1429 - 1433. [Abstract] [Full Text] [PDF]
|
|