© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 15, 1327-1328,
August 4, 1999
© 1999 Oxford University Press
BRIEF COMMUNICATION |
Evidence for the Colonic Origin of Ovarian Cancer Cell Line SW626
Affiliations of authors: M. T. Furlong, C. D. Hough, C. A. Sherman-Baust, P. J. Morin, Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging, Baltimore, MD; E. S. Pizer, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore.
Correspondence to: Patrice J. Morin, Ph.D., Laboratory of Biological Chemistry, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Dr., Baltimore, MD 21224 (e-mail: morinp@grc.nia.nih.gov).
Cancer cell lines are an essential tool of cancer research, but
their origin can sometimes be difficult to determine with certainty. In
addition to contamination with other cell lines during in vitrocultivation, errors can arise during the initial resection from the
patient because the organ of origin can sometimes be difficult to
determine. This is particularly problematic for ovarian cancer, where a
substantial fraction of the cases represent metastases from distant
nongenital sites (1). Once in culture and without detailed
patient data, it can be difficult or impossible to trace the origin of
a particular cell population. The difficulty arises from the fact that
cells tend to lose
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