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JNCI Journal of the National Cancer Institute 1999 91(13):1159-1160; doi:10.1093/jnci/91.13.1159
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 13, 1159-1160, July 7, 1999
© 1999 Oxford University Press

BRIEF COMMUNICATIONS

Renal Cell Cancer: Chromosome 3 Translocations as Risk Factors

Ad Geurts van Kessel, Hanncke Wijnhoven, Danielle Bodmer, Marc Eleveld, Lambartus Kiemeney, Peter Mulders, Marian Weterman, Marjolijn Ligtenberg, Dominique Smeets, Arie Smits

Affiliations of authors: A. Geurts van Kessel, H. Wijnhoven, D. Bodmer, M. Eleveld, M. Weterman, M. Ligtenberg, D. Smeets, A. Smits (Department of Human Genetics), L. Kiemeney (Departments of Epidemiology and Urology), P. Mulders (Department of Urology), University Hospital Nijmegen, The Netherlands.

Correspondence to: Ad Geurts van Kessel, Ph.D., Department of Human Genetics, University Hospital, P. O. Box 9101, 6500 HB Nijmegen, The Netherlands.

Renal cell cancer (RCC) is relatively rare, with overall incidence rates of approximately five per 100 000 (1). The disease can be cured only by surgery if detected early and clinically restricted to the organ, that is, without metastasis. Usually, RCCs occur as sporadic tumors, but hereditary RCCs have also been reported in particular as a consequence of von Hippel-Lindau (VHL) disease (2). Until recently, two families with RCC and with balanced chromosomal translocations were reported. In the first family, a constitutional translocation t(3;8)(p14;q24) (i.e., a genetic exchange between position p14 of chromosome 3 and position q24 of chromosome . . . [Full Text of this Article]

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