© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 12, 1067-1072,
June 16, 1999
© 1999 Oxford University Press
REPORTS |
Urinary 2-Hydroxyestrone/16
-Hydroxyestrone Ratio and Risk of Breast Cancer in Postmenopausal Women
Affiliations of authors: G. Ursin, A. Paganini-Hill, R. K Ross, M. C. Pike, Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles; S. London, National Institute of Environmental Health Sciences, Research Triangle Park, NC; F. Z. Stanczyk, E. Gentzschein, Department of Obstetrics and Gynecology, University of Southern California/Los Angeles County Women's Hospital. .
Correspondence to: Giske Ursin, M.D., Ph.D., Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Ave., MS #44, Suite 4407, Los Angeles, CA 90033.
BACKGROUND: It has been suggested that women who metabolize a larger proportion of
their endogenous estrogen via the 16
-hydroxylation pathway may be at elevated risk of
breast cancer compared with women who metabolize proportionally more estrogen via the
2-hydroxylation pathway. However, the supporting epidemiologic data are scant. Consequently,
we compared the ratio of urinary 2-hydroxyestrone (2-OHE1) to
16-hydroxyestrone (16-OHE1) in postmenopausal women with breast
cancer and in healthy control subjects. METHODS: Estrogen metabolites were measured in
urine samples obtained from white women who had participated in a previous population-based,
breast cancer case-control study at our institution. All P values are from two-sided tests.
RESULTS: All of the urinary estrogens measured, with the exception of estriol, were higher
in the 66 case patients than in the 76 control subjects. The mean value of urinary 2-OHE1 in case patients was 13.8% (P = .20) higher than that in control
subjects, 16-OHE1 was 12.1% (P = .23) higher, estrone
was 20.9% higher (P = .14), and 17ß-estradiol was 12.0%
higher (P = .36). The ratio of 2-OHE1 to 16-OHE1
was 1.1% higher in the patients (P = .84), contrary to the hypothesis.
Compared with women in the lowest third of the values for the ratio of urinary 2-OHE1 to 16-OHE1, women in the highest third were at a nonstatistically
significantly increased risk of breast cancer (odds ratio = 1.13; 95% confidence
interval = 0.46-2.78), again contrary to the hypothesis. CONCLUSION: This study
does not support the hypothesis that the ratio of the two hydroxylated metabolites (2-OHE1/16-OHE1) is an important risk factor for breast cancer.
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