© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 10, 882-885,
May 19, 1999
© 1999 Oxford University Press
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Prevalence of Mutations in the BRCA1 Gene Among Chinese Patients With Breast Cancer
Affiliations of authors: N. L. S. Tang, C.-P. Pang, K.-W. Choy, L. K. Law, M. Hjelm (Department of Chemical Pathology), W. Yeo, P. Johnson (Department of Clinical Oncology), P. K. Lam, W. W. K. King (Department of Surgery), M. Suen (Department of Anatomical and Cellular Pathology), Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Correspondence to:Nelson L. S. Tang, F.R.C.P.A., Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China (e-mail: nelsontang@cuhk.edu.hk).
Inherited mutations in the tumor susceptibility genes BRCA1 and BRCA2 account for about 70%-90% of familial breast cancer in most Caucasian populations while BRCA1 mutations alone contribute to about half of the cases (1-3). Epidemiologic data from Caucasians show that BRCA1 mutations occur in the general population at a frequency between 0.05% and 0.2%. BRCA1 mutations account for about 5% of all breast cancers and up to 12% of early-onset breast cancers (3,4). The relative contribution of BRCA2 may be slightly lower (2,3).
The BRCA1 tumor suppressor gene is composed of 22 coding and two noncoding exons (5,6). The BRCA1 protein may play a role in cell cycle regulation (7) and control of DNA repair (8,9). More than
300 heritable mutations in the BRCA1 gene have been found
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