© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 1, 86-88,
January 6, 1999
© 1999 Oxford University Press
BRIEF COMMUNICATION |
Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer
Affiliations of authors: S. Ambs, W. P. Bennett, W. G.Merriam, M. O. Ogunfusika, S. M. Oser, A. M. Harrington, P. G. Shields, S. P. Hussain, C. C. Harris, Laboratory of Human Carcinogenesis, Division of Basic Sciences, National Cancer Institute, Bethesda, MD; E. Felley-Bosco, Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland.
Correspondence to: Curtis C. Harris, M.D., National Institutes of Health, Bldg. 37, Rm. 2C01, 37 Convent Dr. MSC 4255, Bethesda, MD 20892-4255 (e-mail: Curtis_Harris@nih.gov).
Inducible Ca2+-independent nitric oxide synthase (NOS), also referred to as NOS2, which is expressed in a variety of human cancers (1-4), can generate mutagenic concentrations of nitric oxide (NO) in mice (5). NOS2 is the most active isoform among the three known nitric oxide synthases (6), which also include the neuronal (NOS1) and endothelial (NOS3) isoforms. Only NOS2 is capable of producing sustained NO concentrations in the micromolar range (7).
We investigated the hypothesis that NO generated by NOS2 is capable of
inducing mutations in the p53 (also known as TP53) gene and contributes
to human colon carcinogenesis. We analyzed 118 sporadic colon tumors
for NOS2 expression and p53 gene mutations. Colon tumors and
surrounding normal tissues were collected from the Cooperative Human
Tissue Network and the Department of Pathology, University of
Baltimore, with the approval of local boards
NOTES
REFERENCES
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Islami, A. Pourshams, D. Nasrollahzadeh, F. Kamangar, S. Fahimi, R. Shakeri, B. Abedi-Ardekani, S. Merat, H. Vahedi, S. Semnani, et al. Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study BMJ, March 26, 2009; 338(mar26_2): b929 - b929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zhang, A. Ma, S. J. Urbanski, and D.-M. McCafferty Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma Carcinogenesis, May 1, 2007; 28(5): 1122 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hagiwara, L. E. Mechanic, G. E. Trivers, H. L. Cawley, M. Taga, E. D. Bowman, K. Kumamoto, P. He, M. Bernard, S. Doja, et al. Quantitative Detection of p53 Mutations in Plasma DNA from Tobacco Smokers Cancer Res., August 15, 2006; 66(16): 8309 - 8317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Besaratinia and G. P. Pfeifer Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis Carcinogenesis, August 1, 2006; 27(8): 1526 - 1537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hanada, T. Kobayashi, T. Chinen, K. Saeki, H. Takaki, K. Koga, Y. Minoda, T. Sanada, T. Yoshioka, H. Mimata, et al. IFN{gamma}-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice J. Exp. Med., June 12, 2006; 203(6): 1391 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Le Calvez, A. Mukeria, J. D. Hunt, O. Kelm, R. J. Hung, P. Taniere, P. Brennan, P. Boffetta, D. G. Zaridze, and P. Hainaut TP53 and KRAS Mutation Load and Types in Lung Cancers in Relation to Tobacco Smoke: Distinct Patterns in Never, Former, and Current Smokers Cancer Res., June 15, 2005; 65(12): 5076 - 5083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kashfi, S. Borgo, J. L. Williams, J. Chen, J. Gao, A. Glekas, F. Benedini, P. del Soldato, and B. Rigas Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 978 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. De Bont and N. van Larebeke Endogenous DNA damage in humans: a review of quantitative data Mutagenesis, May 1, 2004; 19(3): 169 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Hofseth, A. I. Robles, Q. Yang, X. W. Wang, S. P. Hussain, and C. Harris p53: At the Crossroads of Molecular Carcinogenesis and Molecular Epidemiology Chest, May 1, 2004; 125(5_suppl): 83S - 85S. [Full Text] [PDF]
|
|
|
|
|
|
G.J.S. Jenkins REVIEW The restriction site mutation (RSM) method: clinical applications Mutagenesis, January 1, 2004; 19(1): 3 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Crott, S.-W. Choi, J. M. Ordovas, J. S. Ditelberg, and J. B. Mason Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis Carcinogenesis, January 1, 2004; 25(1): 69 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dhar, J. M. Brindley, C. Stark, M. L. Citro, L. K. Keefer, and N. H. Colburn Nitric oxide does not mediate but inhibits transformation and tumor phenotype Mol. Cancer Ther., December 1, 2003; 2(12): 1285 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Crowell, V. E. Steele, C. C. Sigman, and J. R. Fay Is Inducible Nitric Oxide Synthase a Target for Chemoprevention? Mol. Cancer Ther., August 1, 2003; 2(8): 815 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Casson, S. C. Evans, A. Gillis, G. A. Porter, P. Veugelers, S. J. Darnton, D. L. Guernsey, and P. Hainaut Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: Results of a ten-year prospective study J. Thorac. Cardiovasc. Surg., May 1, 2003; 125(5): 1121 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cianchi, C. Cortesini, O. Fantappie, L. Messerini, N. Schiavone, A. Vannacci, S. Nistri, I. Sardi, G. Baroni, C. Marzocca, et al. Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer: Correlation with Tumor Angiogenesis Am. J. Pathol., March 1, 2003; 162(3): 793 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Phoa and B. Epe Influence of nitric oxide on the generation and repair of oxidative DNA damage in mammalian cells Carcinogenesis, March 1, 2002; 23(3): 469 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Marrogi, M. A. Khan, H. E. van Gijssel, J. A. Welsh, H. Rahim, A. J. Demetris, K. V. Kowdley, S. P. Hussain, J. Nair, H. Bartsch, et al. Oxidative Stress and p53 Mutations in the Carcinogenesis of Iron Overload-Associated Hepatocellular Carcinoma J Natl Cancer Inst, November 7, 2001; 93(21): 1652 - 1655. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Jaiswal, N. F. LaRusso, and G. J. Gores Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G626 - G634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Kobayashi, H. Miwa, S. Watanabe, M. Tsujii, R. N. Dubois, and N. Sato Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G688 - G696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. P. Hao, T. G. Pretlow, J. S. Rao, and T. P. Pretlow Inducible Nitric Oxide Synthase (iNOS) Is Expressed Similarly in Multiple Aberrant Crypt Foci and Colorectal Tumors from the Same Patients Cancer Res., January 1, 2001; 61(2): 419 - 422. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. P. Hussain, K. Raja, P. A. Amstad, M. Sawyer, L. J. Trudel, G. N. Wogan, L. J. Hofseth, P. G. Shields, T. R. Billiar, C. Trautwein, et al. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases PNAS, October 23, 2000; (2000) 220416097. [Abstract] [Full Text]
|
|
|
|
|
|
S. P. Hussain, P. Amstad, K. Raja, S. Ambs, M. Nagashima, W. P. Bennett, P. G. Shields, A.-J. Ham, J. A. Swenberg, A. J. Marrogi, et al. Increased p53 Mutation Load in Noncancerous Colon Tissue from Ulcerative Colitis: A Cancer-prone Chronic Inflammatory Disease Cancer Res., July 1, 2000; 60(13): 3333 - 3337. [Abstract] [Full Text]
|
|
|
|
|
|
L. J. Marnett Oxyradicals and DNA damage Carcinogenesis, March 1, 2000; 21(3): 361 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Souici, J. Mirkovitch, P. Hausel, L. K.Keefer, and E. Felley-Bosco Transition mutation in codon 248 of the p53 tumor suppressor gene induced by reactive oxygen species and a nitric oxide-releasing compound Carcinogenesis, February 1, 2000; 21(2): 281 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Gallo, I. Sardi, M. Masini, and A. Franchi Re: Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer J Natl Cancer Inst, September 1, 1999; 91(17): 1509 - 1510. [Full Text] [PDF]
|
|
|
|
|
|
S. Ambs and C. C. Harris RESPONSE: Re: Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer J Natl Cancer Inst, September 1, 1999; 91(17): 1510 - 1511. [Full Text] [PDF]
|
|
|
|
|
|
S. P. Hussain, K. Raja, P. A. Amstad, M. Sawyer, L. J. Trudel, G. N. Wogan, L. J. Hofseth, P. G. Shields, T. R. Billiar, C. Trautwein, et al. Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases PNAS, November 7, 2000; 97(23): 12770 - 12775. [Abstract] [Full Text] [PDF]
|
|