© 1995 by Oxford University Press
Journal of the National Cancer Institute, Vol. 87, No. 19, 1446-1455,
October 4, 1995
© 1995 Oxford University Press
Genetic Services for Familial Cancer Patients: A Survey of National Cancer Institute Cancer Centers
Department of Genetics and Cell Biology, University of Minnesota Minneapolis
Division of Epidemiology, University of Minnesota Minneapolis
Division of Genetics and Metabolism, University of Minnesota Minneapolis
University of Minnesota Cancer Center, University of Minnesota Minneapolis
Department of Genetics and the Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland Cleveland, OH
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center Seattle, WA.
*Correspondence to: Georgia L. Wiesner, M.D., Department of Genetics, Case Western Reserve University, 10900 Euclid Ave., Biomedical Research Building #747, Cleveland, OH 44106-4955.
In the past d3ecade, significant progress has been made in understanding the genetic component of familial cancers.Genes associated with familial colon and breast cancers have recently been isolated and molecular diagnostic tests are expected to become available in the near future. Clinicians now have the opportunity to recognize and counsel individuals with elevated risk of cancer by identifying risk factors and genes associated with cancer predisposition. The rapid advances in molecular technology are a direct challenge to the medical community and cancer centers to supply specialized clinical services for familial cancers. We sought to ascertain the activities of cancer centers in the development of programs and the provision of genetic services for familial cancer. We surveyed 41 centers with National Cancer Institute (NCI) cancer center support grants. One half of the centers responding (17 of 34) reported that they provide some genetic services for familial cancer. About one half of these 17 centers (eight [57%] of 14; the three remaining clinics that responded had incomplete information on this indicator) see a variety of patient types on a small scale (fewer than 100 patients per year), and most provide four basic clinical evaluations: medical evaluation, cancer risk assessment, genetic counseling, and pedigree analysis. Staffing of each center varied widely, as did the types of screening services offered (including molecular diagnostic testing). Several centers (six [35%] of 17) indicated that they were in the developmental stages for serving familial cancer patients, and many seem to be increasing their activities in this area. The remaining 17 NCI-supported centers that responded, however, currently provide no genetic services for familial cancers. The results of this survey suggest that there is interest in developing clinical programs for familial cancers by NCI-supported cancer centers, but most of these programs are in developmental stages. A base line has been established to monitor future progress for the provision of cancer genetic services. [J Natl Cancer Inst 1995; 87:1446–55]
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