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JNCI Journal of the National Cancer Institute 1991 83(7):496-501; doi:10.1093/jnci/83.7.496
© 1991 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 83, No. 7, 496-501, April 3, 1991
© 1991 Oxford University Press

Modulation of N-Nitrosomethylurea-Induced Mammary Tumor Promotion by Dietary Fiber and Fat

L. A. Cohen*, M. E. Kendall, E. Zang, C. Meschter, D. P. Rose

Division of Nutrition and Endocrinology, American Health Foundation Valhalla, NY

*Correspondance to: L. A. Cohen, Phd, Division of Nutrition and Endocrinology, American Health Foundation, I Dana Rd, Valhalla, NY 10595.

A test of the anticancer effects of dietary fiber was conducted using the N-nitrosomethylurea (NMU)-induced rat mammary tumor model. Starting 3 days after NMU treatment, four different groups of F344 rats (30 rats in each group) were fed as follows: Group 1 received a high-fat diet; group 2, a high-fat plus fiber diet (soft white wheat bran, 10% wt/wt); group 3, a low-fat diet; and group 4, a low-fat plus fiber diet. The rats remained on these diets for 15 weeks. Tumor incidence in group 1 was 90% compared with 66% in group 2 (P<.001). Tumor incidence in group 3 was 63% compared with 47% in group 4 (P>.4). These results show that supplemental dietary fiber exerts an inhibitory effect on the promotional phase of NMU-induced mammary carcinogenesis in rats when fed a high-fat but not a low-fat diet. To test whether fiber may exert its antipromoting effect by reducing circulating estrogens, serum 17beta-estradiol was assayed. No changes were observed in serum 17beta-estradiol levels among the four groups, suggesting that the protective effect of fiber in this animal model is not mediated by a fiber-induced reduction of circulating 17beta-estradiol. [J Natl Cancer Inst 83: 496–501, 1991]


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