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JNCI Journal of the National Cancer Institute 1990 82(10):861-864; doi:10.1093/jnci/82.10.861
© 1990 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 82, No. 10, 861-864, May 16, 1990
© 1990 Oxford University Press

Effect of Nicotine on 7,12-Dimethylbenz[a]anthracene Carcinogenesis in Hamster Cheek Pouch

Yi-Ping Chen, Christopher A. Squier*

Dows Institute for Dental Research, College of Dentistry, The University of Iowa Iowa City, IA

*Correspondence to: Christopher A. Squier, Ph.D., D.Sc., Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242.

We divided 40 male Syrian golden hamsters into four groups of 10 animals each, and we treated both cheek pouches of each hamster three times a week as follows: group 1, 50 µL of sesame oil; group 2, 50 µL of 6% nicotine in sesame oil; group 3, 50 µL of 1% 7, 12-dimethylbenz[a]anthracene (DMBA) in sesame oil; and group 4, 50 µL of 1% DMBA in 6% nicotine in sesame oil. Cheek pouches were examined clinically and histologically after 12 weeks of treatment. Hamsters treated with DMBA and nicotine showed significantly (P< .001) more tumors and a significantly (P< .05) greater-than-expected proportion of large tumors (≥ 3-mm diameter) than hamsters treated with DMBA alone. Histologically, there was a greater degree of dysplasia in lesions from the group receiving DMBA plus nicotine than in the DMBA only group. The results suggest that nicotine acts as a cofactor in DMBA tumorigenesis. [J Natl Cancer Inst 82:861–864, 1990]


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