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JNCI Journal of the National Cancer Institute 1989 81(24):1874-1878; doi:10.1093/jnci/81.24.1874
© 1989 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 81, No. 24, 1874-1878, December 20, 1989
© 1989 Oxford University Press

Isochromosome of Chromosome 12: Clinically Useful Marker for Male Germ Cell Tumors

J.George Bosl*, Ethan Dmitrovsky, Victor E. Reuter, Felipe Samaniego, Eduardo Rodriguez, Nancy L. Geller, R. S. K. Chaganti

*Correspondence to: George J. Bosl, M.D., Division of Solid Tumor Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021.

Twenty-nine tumor specimens were obtained from 24 males with germ cell tumors. AD primary sites and histologies were represented. An isochromosome of the short arm of chromosome 12 [i (12p)] was found in 20 specimens obtained from 16 patients, a 46, XY normal karyotype was present in seven specimens, and one specimen was a cytogenetk failure. The i(12p) was found in tumors from all primary sites and in all histologies, including a choriocardnoma. The presence of three or more additional copies of 12p was associated with a statistically significant greater likelihood of treatment failure. With diagnostic and possibly prognostic importance in germ cell tumors in males, the high frequency of i(12p) in our series of studies and in those of others indicates that it probably occurs as a very early defect in the development of these tumors. Further studies of chromosome 12 in males with these tumors are warranted. [J Natl Cancer Inst 81: 1874–1878, 1989].


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