Skip Navigation

JNCI Journal of the National Cancer Institute 1988 80(1):56-60; doi:10.1093/jnci/80.1.56
© 1988 by Oxford University Press
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Nelson, J. S.
Right arrow Articles by Berns, M. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nelson, J. S.
Right arrow Articles by Berns, M. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 80, No. 1, 56-60, March 2, 1988
© 1988 Oxford University Press

Photodynamic Therapy of Human Malignant Melanoma Xenografts in Athymic Nude Mice12

J. Stuart Nelson3,4, Jerry L. McCullough5, Michael W. Berns3,4,5,6

3Department of Surgery, University of California at Irvine Irvine, CA 92717.
4Beckman Laser Institute and Medical Clinic, University of California at Irvine 1002 Health Sciences Rd. East, Irvine, CA.
5Department of Dermatology, University of California at Irvine

While photodynamic therapy (PDT) for cutaneous malignancies including dermal recurrences of breast cancer and basal cell carcinomas has shown great promise, PDT of malignant melanoma has remained incompletely understood. A comparison study of the effects of PDT on human xenograft amelanotic and melanotic malignant melanoma in the athymic nude mouse model was performed. Twenty-four hours after ip administration of Photofrin II, the responses to total laser light doses of 25–300 J/cm2 were evaluated by histologic examination. Animals were also sacrificed 24 hours after administration of Photofrin II without light, and their uptake and localization of hematoporphyrin derivative (HpD) for each tumor were measured and compared. The results indicate that human xenograft melanotic melanoma, despite the fact that it contains more HpD than does amelanotic melanoma, is far less responsive to PDT. This result appears to be due to the competing chromophore melanin, which may inhibit the photochemical reaction at several key points. [J Natl Cancer Inst 1988;80:56–60]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
M. Makowski, T. Grzela, J. Niderla, M. Lazarczyk, P. Mroz, M. Kopee, M. Legat, K. Strusinska, K. Koziak, D. Nowis, et al.
Inhibition of Cyclooxygenase-2 Indirectly Potentiates Antitumor Effects of Photodynamic Therapy in Mice
Clin. Cancer Res., November 1, 2003; 9(14): 5417 - 5422.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
E. F. Bernstein, W. S. Friauf, P. D. Smith, J. W. Cole, R. E. Solomon, J. F. Fessler, G. F. Thomas, C. Black, and A. Russo
Transcutaneous Determination of Tissue Dihematoporphyrin Ether Content: A Device to Optimize Photodynamic Therapy
Arch Dermatol, December 1, 1991; 127(12): 1794 - 1798.
[Abstract] [PDF]

Home page
 Arch DermatolHome page
E. F. Bernstein, G. F. Thomas, P. D. Smith, J. B. Mitchell, E. Glatstein, G. R. Kantor, R. L. Spielvogel, S. C. Maiese, and A. Russo
Response of Black and White Guinea Pig Skin to Photodynamic Treatment Using 514-nm Light and Dihematoporphyrin Ether
Arch Dermatol, October 1, 1990; 126(10): 1303 - 1307.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.