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Journal of the National Cancer Institute Advance Access originally published online on June 30, 2009
JNCI Journal of the National Cancer Institute 2009 101(14):973-975; doi:10.1093/jnci/djp184
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© The Author 2009. Published by Oxford University Press.

EDITORIALS

Breast Cancer Single-Nucleotide Polymorphisms: Statistical Significance and Clinical Utility

Kenneth Offit

Affiliation of author: Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY

Correspondence to: Kenneth Offit, MD, MPH, Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021 (e-mail: offitk@mskcc.org).

The first 10% of the full text of this article appears below.

The completion of nine large genome-wide association studies (1–9) has focused attention on single-nucleotide polymorphisms (SNPs) as risk factors for breast cancer. Despite considerable progress, the scientific yield, practical application, and commercial exploitation of SNP profiling for disease risk remain topics of debate (10–13).

In this context, the study by Milne et al. (14) offers an excellent example of both the promise and challenges of current genetic epidemiological approaches to SNP genotyping for breast cancer risk. Drawing on an international consortium of 25 centers contributing DNA from more than 30 000 breast cancer case patients and 35 000 healthy control subjects, these investigators sought to confirm . . . [Full Text of this Article]


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J Natl Cancer Inst 2009 101: 969. [Extract] [Full Text] [PDF]