Skip Navigation


Journal of the National Cancer Institute Advance Access originally published online on December 30, 2008
JNCI Journal of the National Cancer Institute 2009 101(1):2-4; doi:10.1093/jnci/djn453
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
101/1/2    most recent
djn453v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Albanes, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Albanes, D.
Related Collections
Right arrowRelated Articles in JNCI
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2008.

EDITORIALS

Vitamin Supplements and Cancer Prevention: Where Do Randomized Controlled Trials Stand?

Demetrius Albanes

Affiliation of author: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD

Correspondence to: Demetrius Albanes, MD, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, Room 3044, Bethesda, MD 20892 (e-mail:daa@nih.gov).

The first 150 words of the full text of this article appear below.

Cancer chemoprevention as a concept and research methodology that examines inhibition of human carcinogenesis by nutritional, phytochemical, and other pharmacological substances dates to at least the early 1980s (1,2). At that time, a flurry of chemoprevention trials was launched predicated on epidemiological observations regarding potential protective roles for a wide range of foods and nutrients, including retinoids, beta carotene, calcium, and lower dietary fat in several cancers, and on basic research that provided both corroboration of the hypotheses through tumor inhibition in experimental models and evidence relevant to the responsible biological mechanisms. However, only a few of the randomized controlled studies, or RCT’s, have demonstrated the hoped-for reductions—or even unanticipated benefits—in incidence or recurrence of neoplasia from nutrient supplementation or dietary modification. For example, the Nutritional Prevention of Cancer Study, which aimed to prevent nonmelanoma skin cancers with selenized yeast, failed to do so, but unexpected . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related Articles in JNCI

IN THIS ISSUE
J Natl Cancer Inst 2009 101: 1. [Extract] [Full Text] [PDF]

Vitamins C and E and Beta Carotene Again Fail to Reduce Cancer Risk in Randomized Controlled Trial
J Natl Cancer Inst 2009 101: 1. [Extract] [Full Text] [PDF]