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Journal of the National Cancer Institute Advance Access originally published online on December 9, 2008
JNCI Journal of the National Cancer Institute 2008 100(24):1822-1823; doi:10.1093/jnci/djn405
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© The Author 2008. Published by Oxford University Press.

CORRESPONDENCE

Umbilical Cord Blood Transplantation: Should Perinatal Solid Cancer Become a Matter of Concern?

Maria Valeria Corrias, Sandro Dallorso, Riccardo Haupt, Irene Martini, Fabio Morandi, Barbara Carlini, Vito Pistoia, Alberto Garaventa

Affiliations of Authors: Laboratory of Oncology (MVC, FM, BC, VP), Department of Haematology-Oncology (SD, AG), and Epidemiology and Biostatistics Section, Scientific Directorate (RH), Gaslini Institute, Genoa, Italy; SmartBank, Roma, Italy (IM)

Correspondence to: Maria Valeria Corrias, PhD, Laboratory of Oncology, Gaslini Institute, Largo Gaslini, 5, 16148 Genoa, Italy (e-mail: mariavaleriacorrias@ospedale-gaslini.ge.it).

The first 10% of the full text of this article appears below.

Umbilical cord blood (UCB) is increasingly being used as an alternative source of hematopoietic stem cells in patients with inherited diseases or hematologic malignancies. These cells, despite the risk of delayed engraftment, are of great interest for their rapid availability, low risk of virus transmission, and reduced risk of graft vs host disease. Whereas sometimes the cord blood is stored for possible autologous transplantation, it is generally used for allogeneic recipients. We would like to warn clinicians that in such cases, there is a risk of transmitting circulating cells from pediatric malignancies.

We obtained UCB that had been stored by the parents of . . . [Full Text of this Article]

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