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Journal of the National Cancer Institute Advance Access originally published online on September 23, 2008
JNCI Journal of the National Cancer Institute 2008 100(19):1341-1343; doi:10.1093/jnci/djn327
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© The Author 2008. Published by Oxford University Press.

EDITORIALS

Menopausal Hormone Therapy in BRCA1 Mutation Carriers: Uncertainty and Caution

Rowan T. Chlebowski, Ross L. Prentice

Affiliations of authors: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (RTC); Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (RLP)

Correspondence to: Rowan T. Chlebowski, MD, PhD, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 Carson St, Torrance, CA 90502 (e-mail: rchlebowski@gmail.com).

The first 10% of the full text of this article appears below.

Previous observational studies suggest that oophorectomy substantially reduces breast cancer risk in women with BRCA mutations (1) and that this association is not abrogated by hormone therapy (2). In a case–control study of women with deleterious BRCA1 mutations, Eisen et al. (3) attempt to extend these findings regarding hormone therapy use in postmenopausal BRCA1 mutation carriers. The authors conclude that use of hormone therapy, including combined estrogen plus progestin and estrogen alone, does not appear to be associated with increased risk of breast cancer and may be associated with decreased risk.

This provocative result—especially regarding combined hormone therapy use, which potentially could inform current clinical practice—raises several issues. Are there study design concerns that bring . . . [Full Text of this Article]


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Hormone Therapy and the Risk of Breast Cancer in BRCA1 Mutation Carriers
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