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Journal of the National Cancer Institute Advance Access originally published online on July 8, 2008
JNCI Journal of the National Cancer Institute 2008 100(14):976-977; doi:10.1093/jnci/djn225
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© The Author 2008. Published by Oxford University Press.

EDITORIALS

Cancer as a Ferrotoxic Disease: Are We Getting Hard Stainless Evidence?

Gustaf Edgren, Olof Nyrén, Mads Melbye

Affiliations of authors: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (GE, ON); Division of Epidemiology, Statens Serum Institut, Copenhagen, Denmark (MM)

Correspondence to: Mads Melbye, MD, PhD, Department of Epidemiology Research, Statens Serum Institut, 5 Artillerivej, Copenhagen S, DK-2300, Denmark (e-mail: mme@ssi.dk).

The first 10% of the full text of this article appears below.

Iron is an essential mineral to all human tissues. Incorporated in the heme complex, it is necessary for the hemoglobin-borne transport of oxygen and generation of ATP in the electron transport chain. But iron may also have direct toxic effects, and iron uptake is consequentially tightly regulated in the human body (1). Recognizing the pro-oxidative properties of iron and its tendency to accumulate with age in properly nourished individuals, investigators have hypothesized that iron might be involved in the causation of many of the chronic diseases that are linked to a Western lifestyle (2–4), and believers have coined the term "ferrotoxic" disease (5). For example, sex differences in iron levels have been hypothesized to contribute to the differences between men and women in the risk of cardiovascular disease (6).

Iron has long . . . [Full Text of this Article]


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