Journal of the National Cancer Institute Advance Access originally published online on May 27, 2008
JNCI Journal of the National Cancer Institute 2008 100(11):759-761; doi:10.1093/jnci/djn164
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© The Author 2008. Published by Oxford University Press.
EDITORIALS |
Vitamin D and Prostate Cancer Risk—A Less Sunny Outlook?
Affiliations of authors: Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (LAM); Departments of Epidemiology (LAM, DS) and Biostatistics (DS), Harvard School of Public Health, Boston, MA
Correspondence to: Donna Spiegelman, ScD, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115 (e-mail: stdls@channing.harvard.edu).
| The first 150 words of the full text of this article appear below. |
Vitamin D insufficiency is an emerging public health concern. National survey data confirm that large proportions of the populations in the United States and Northern Europe have low vitamin D levels (1,2). The prevalence of low vitamin D levels looms particularly large among African Americans and others with dark skin (3), the elderly, the overweight (4) and physically inactive, and those with little sun exposure, such as those who live at higher latitudes where sun exposure in the winter does not induce vitamin D formation in skin (5). Interest in vitamin D levels stems from the growing recognition that the low vitamin D levels that are sufficient to avoid rickets, the classical deficiency disease, may be suboptimal for overall health. The associations with low vitamin D range from increases in total mortality (6), cardiovascular disease (7),
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