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Journal of the National Cancer Institute Advance Access originally published online on May 13, 2008
JNCI Journal of the National Cancer Institute 2008 100(10):753-754; doi:10.1093/jnci/djn130
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© The Author 2008. Published by Oxford University Press.

CORRESPONDENCE

Response: Re: Molecular Basis for Estrogen Receptor {alpha} Deficiency in BRCA1-Linked Breast Cancer

Alison M. Hosey, Julia J. Gorski, Jennifer E. Quinn, Wen Y. Chung, Amanda Mccann, D. Paul Harkin

Affiliations of authors: Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK (AMH, JJG, JEQ, DPH); University College Dublin School of Medicine and Medical Science and the UCD Conway Institute of Biomolecular and Biomedical Science, Dublin, Ireland, UK (WYC, AM)

Correspondence to: D. Paul Harkin, PhD, Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK (e-mail: d.harkin@qub.ac.uk).

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We thank Lusa et al. for their interest in our study and would like to address some of their findings. They provide data on the correlation between BRCA1 mRNA levels and estrogen receptor (ER) status as assessed by immunohistochemistry (IHC). Tumor sections were scored as ER positive if at least 10% of the tumor cells were labeled (1). They found that tumor . . . [Full Text of this Article]


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Related Correspondence

Re: Molecular Basis for Estrogen Receptor {alpha} Deficiency in BRCA1-Linked Breast Cancer
Lara Lusa, Bernard Peissel, Siranoush Manoukian, Edoardo Marchesi, Paolo Radice, Marco A. Pierotti, and Manuela Gariboldi
J Natl Cancer Inst 2008 100: 752-753. [Extract] [Full Text] [PDF]