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Journal of the National Cancer Institute Advance Access originally published online on December 25, 2007
JNCI Journal of the National Cancer Institute 2008 100(1):6-10; doi:10.1093/jnci/djm301
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© Oxford University Press 2007.

NEWS

MEDAL FOR MOUSE MEDDLING

Knockout Mouse Creation Wins Nobel Prize

Mary Beckman

The first 10% of the full text of this article appears below.

The ability to delete or mutate any gene of interest in mice has transformed the landscape of mammalian biology research. In early October, the Nobel Prize committee acknowledged the work of three scientists who pioneered gene targeting in mice: Mario R. Capecchi, Ph.D., Martin J. Evans, D.Sc., and Oliver Smithies, D.Phil.


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  		Mario R. Capecchi, Ph.D., Martin J. Evans, D.Sc., and Oliver Smithies, D.Phil., won the Nobel Prize in Medicine this year for work that allowed researchers to knock out or mutate specific genes in mouse models. It has had a major impact on cancer research.

 
Cancer biologists were among the first to begin using this method, which has dramatically increased their knowledge about how cancers form and grow. Since the early 1990s, researchers have created hundreds of strains of mice with precise mutations, which they are using to gradually piece together the puzzle of the deadly disease.

. . . [Full Text of this Article]


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