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Journal of the National Cancer Institute Advance Access originally published online on July 10, 2007
JNCI Journal of the National Cancer Institute 2007 99(14):1057; doi:10.1093/jnci/djm088
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© Oxford University Press 2007.

MEMO TO THE MEDIA

Press Release

Kaposi Sarcoma Arises Independently From Multiple Cells

Liz Savage, Andrea Widener

jncimedia{at}oxfordjournals.org
301-841-1287

Kaposi sarcoma is unique among cancers because most tumors grow from a small number of different cells, whereas nearly all other cancers arise from a single cell, according to a study published online July 10 in the Journal of the National Cancer Institute.

Kaposi sarcoma, which is often associated with AIDS, primarily affects the skin. But as the disease progresses, it can move to the lymph nodes and internal organs as well.

Renan Duprez, Ph.D., of the Institut Pasteur in Paris and colleagues performed the largest study to date on the origins of advanced Kaposi sarcoma. Biopsies from 98 Kaposi sarcoma patients were analyzed using molecular diagnostic techniques to compare the viral DNA of the tumors, which often contain human herpesvirus 8.

The researchers found evidence that nearly 80% of the tumors arose independently from multiple cells. They concluded that few Kaposi sarcoma tumors originate from a single cell and that Kaposi sarcoma, especially in its advanced form, is not true metastatic cancer.

In an accompanying editorial, Parkash S. Gill, M.D., of Norris Cancer Hospital and Research Institute in Los Angeles recommends what should come next in Kaposi sarcoma research.

"With some resolution as to the clonal nature of [Kaposi sarcoma] of the skin and lymph node, similar analysis remains to be done for visceral [Kaposi sarcoma], which can be more invasive leading at times to catastrophic organ dysfunction and even death. It is also not known if the clonal [Kaposi sarcoma] lesions identified in this study were more aggressive and less likely to respond to therapy," Gill writes.

Contact:

  • Article: Antoine Gessain, agessain{at}pasteur.fr, +33 0145688937
  • Editorial: Parkash S. Gill, parkashg{at}hsc.usc.edu, (323) 865-3909

Citations:

  • Article: Duprez R, Lacoste V, Brière J, Couppié P, Frances C, et al. Evidence for a Multiclonal Origin of Multicentric Advanced Lesions of Kaposi Sarcoma. J Natl Cancer Inst 2007; 99: 1086–1094
  • Editorial: Gill PS. The Origin of Kaposi Sarcoma. J Natl Cancer Inst 2007; 99: 1063

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The Journal of the National Cancer Institute is published by Oxford University Press and is not affiliated with the National Cancer Institute. Attribution to the Journal of the National Cancer Institute is requested in all news coverage. Visit the Journal online at http://jnci.oxfordjournals.org/.


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Related Articles in JNCI

Evidence for a Multiclonal Origin of Multicentric Advanced Lesions of Kaposi Sarcoma
Renan Duprez, Vincent Lacoste, Josette Brière, Pierre Couppié, Camille Frances, Dominique Sainte-Marie, Eric Kassa-Kelembho, Marie-Jeanne Lando, Jean-Louis Essame Oyono, Blaise Nkegoum, Oumkaltoum Hbid, Antoine Mahé, Céleste Lebbé, Patricia Tortevoye, Michel Huerre, and Antoine Gessain
J Natl Cancer Inst 2007 99: 1086-1094. [Abstract] [Full Text] [PDF]

The Origin of Kaposi Sarcoma
Parkash S. Gill
J Natl Cancer Inst 2007 99: 1063. [Extract] [Full Text] [PDF]




This Article
Right arrow Extract Freely available
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99/14/1057-b    most recent
djm088v1
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Right arrow Articles by Savage, L.
Right arrow Articles by Widener, A.
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Right arrow Articles by Savage, L.
Right arrow Articles by Widener, A.
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