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JNCI Journal of the National Cancer Institute 2006 98(8):561; doi:10.1093/jnci/djj136
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© The Author 2006. Published by Oxford University Press.

CORRESPONDENCE

RESPONSE: Re: Risk of Thyroid Cancer After Exposure to 131I in Childhood

Elisabeth Cardis, Ausrele Kesminiene

Affiliation of authors: International Agency for Research on Cancer, Lyon, France

Correspondence to: Elisabeth Cardis, PhD, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, 69 372, France (e-mail: cardis{at}iarc.fr).

Scott quotes us as stating that we had found a linear no-threshold dose–response relationship in this study. In fact, we did not comment in any way about the existence or not of a threshold. In describing the results, we simply stated that we had observed a strong dose–response relationship and that the odds ratio appeared to increase linearly with dose up to 1.5–2 Gy and then to plateau at higher doses. We were trying to point out what was happening at higher doses, not to comment on what might be happening at very low doses where we have in fact no power to distinguish between models with or without a threshold.

With regard to our analyses of the dose–response relationship using polynomials in dose, these analyses were not conducted on grouped doses. Doses were grouped into categories, and odds ratios were calculated by dose category only for descriptive purposes. All analyses of risk per gray were based on individual data and used dose as a continuous variable.


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Related Correspondence

Re: Risk of Thyroid Cancer After Exposure to 131I in Childhood
Bobby R. Scott
J Natl Cancer Inst 2006 98: 561. [Extract] [Full Text] [PDF]




This Article
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