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In Brief
Diabetes Linked to Cancer in Japanese AdultsJapanese adults with diabetes have an increased risk of cancer, particularly in the liver, pancreas, and kidneys, according to a new study.
Manami Inoue, M.D., Ph.D., of the National Cancer Center in Tokyo, and colleagues examined the link between diabetes and cancer in a study of 97,771 Japanese people between ages 40 and 69. The participants were given an extensive questionnaire detailing their lifestyle and medical history.
The authors found that men with diabetes had a 27% higher chance of developing cancer than men without the disease particularly liver, kidney, and pancreatic cancer. Women with diabetes had a 21% higher risk of developing cancer, particularly stomach and liver cancers.
The study was published in the September 25 issue of the Archives of Internal Medicine.
Starr Foundation Awards Multi–Million Dollar Research Grant to Cancer Centers
The Starr Foundation has awarded a $100 million grant to five cancer research centers. The recipients include the Broad Institute of MIT and Harvard, Cold Spring Harbor Laboratory, Memorial Sloan-Kettering Cancer Center, Rockefeller University, and Weill Cornell Medical College.
The research centers will use the money to focus on improving technologies to assess the genetic and molecular basis of cancer and using those technologies to diagnose and treat cancer. The project will also support basic biological research on the cellular and molecular basis of cancer.
FDA Issues Guidelines to Tissue Manufacturers
The U.S. Food and Drug Administration has issued new guidelines for companies that manufacture cells, tissues, and cellular- and tissue-based products. The rules come after two industry violations of FDA safety requirements.
FDA guidelines require that tissue manufacturers work with human cells or tissue in a way that prevents the spread and transmission of communicable disease and contamination. All manufacturers must comply with these FDA regulations when manufacturing human cells and tissue.
Models of Patient Risk Show Links to Genetic Mutations and Colorectal Cancer
Models that include information about personal and family history can identify patients at high risk of a genetic mutation associated with colorectal cancer, according to a new study.
Judith Balmana, M.D., formerly of the Dana-Farber Cancer Institute in Boston, and colleagues examined data from 1,914 patients who had undergone screening for two genetic mutations (MLH1 and MSH2) associated with Lynch syndrome, an inherited type of colorectal cancer. They created a model to assess a patient's risk of these mutations, and they suggest it may be used to guide a patient's decision to get genetic testing.
The study was published in the September 27 issue of the Journal of the American Medical Association.
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